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Literature summary extracted from
- Suggested functions for prolyl oligopeptidase: a puzzling paradox (2007), Clin. Chim. Acta, 377, 50-61.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | drug development | the enzyme is a potential target for therapy of Chagas' disease | Trypanosoma cruzi |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | POP Tc80, DNA and amino acid sequence determination and anaylsis | Trypanosoma cruzi |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | JTP-4819 | i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-yrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide | Homo sapiens |  |
| 3.4.21.26 | JTP-4819 | i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-yrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide | Mus musculus | |
| 3.4.21.26 | JTP-4819 | i.e. (S)-2-[[(S)-2-(hydroxyacetyl)-1-yrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide, improves learning deficits in rats with dorsal hippocampal lesions | Rattus norvegicus | |
| 3.4.21.26 | additional information | no inhibition by lithium, carbamazepime, desipramine, fluoxetine, and olanzapine | Homo sapiens | |
| 3.4.21.26 | additional information | no inhibition by lithium, carbamazepime, desipramine, fluoxetine, and olanzapine | Mus musculus | |
| 3.4.21.26 | additional information | no inhibition by lithium, carbamazepime, desipramine, fluoxetine, and olanzapine | Rattus norvegicus | |
| 3.4.21.26 | S-17092 | i.e. (2S,3aS,7aS)-1-[[(R,R)-2-phenylcyclopropyl]carbonyl]-2-[(thiazolidin-3-yl)carbonyl] octahydro-1H-indole | Homo sapiens | |
| 3.4.21.26 | S-17092 | i.e. (2S,3aS,7aS)-1-[[(R,R)-2-phenylcyclopropyl]carbonyl]-2-[(thiazolidin-3-yl)carbonyl] octahydro-1H-indole | Mus musculus | |
| 3.4.21.26 | S-17092 | i.e. (2S,3aS,7aS)-1-[[(R,R)-2-phenylcyclopropyl]carbonyl]-2-[(thiazolidin-3-yl)carbonyl] octahydro-1H-indole | Rattus norvegicus | |
| 3.4.21.26 | Valproic acid | - |
Homo sapiens | |
| 3.4.21.26 | Valproic acid | - |
Mus musculus | |
| 3.4.21.26 | Valproic acid | - |
Rattus norvegicus | |
| 3.4.21.26 | ZTTA | i.e. N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal | Homo sapiens | |
| 3.4.21.26 | ZTTA | i.e. N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal | Mus musculus | |
| 3.4.21.26 | ZTTA | i.e. N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylacetal | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.26 | extracellular | the enzyme is secreted into host tissues, overview | Trypanosoma cruzi | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 78000 | - |
x * 78000, about, sequence determination | Trypanosoma cruzi |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | collagens + H2O | Trypanosoma cruzi | in host extracellular matrix | ? | - |
? | |
| 3.4.21.26 | Fibronectin + H2O | Trypanosoma cruzi | in host extracellular matrix | ? | - |
? | |
| 3.4.21.26 | gliadins + H2O | Elizabethkingia meningoseptica | in host gut | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | additional information | Trypanosoma cruzi | enzyme inhibitors are able to prevent the in vitro invasion of rodent muscle cells by trypomastigotes | ? | - |
? | |
| 3.4.21.26 | additional information | Elizabethkingia meningoseptica | the enzyme induces cleavage of gluten-derived peptides predigested by pepsin and pancreatic enzymes an exhibiting a detoxifying effect in the host's gut | ? | - |
? | |
| 3.4.21.26 | additional information | Rattus norvegicus | the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition also positively affects neurodiseases, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Mus musculus | the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition positively affects neurodiseases, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Homo sapiens | the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition positively affects neurodiseases, overview | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Elizabethkingia meningoseptica | - |
- |
- |
| 3.4.21.26 | Homo sapiens | - |
- |
- |
| 3.4.21.26 | Mus musculus | - |
- |
- |
| 3.4.21.26 | Rattus norvegicus | - |
- |
- |
| 3.4.21.26 | Trypanosoma cruzi | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | the catalytic triad is formed by conserved residues Ser548, Asp631, and His667 | Trypanosoma cruzi |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | brain | - |
Mus musculus | - |
| 3.4.21.26 | brain | - |
Homo sapiens | - |
| 3.4.21.26 | brain | - |
Rattus norvegicus | - |
| 3.4.21.26 | epimastigote | low enzyme expression | Trypanosoma cruzi | - |
| 3.4.21.26 | additional information | no enzyme in pancreatic/intestinal brush border membranes | Mus musculus | - |
| 3.4.21.26 | additional information | no enzyme in pancreatic/intestinal brush border membranes | Homo sapiens | - |
| 3.4.21.26 | additional information | no enzyme in pancreatic/intestinal brush border membranes | Rattus norvegicus | - |
| 3.4.21.26 | additional information | wide distribution in host tissues, regulated expression during pathogen life cyce, overview | Trypanosoma cruzi | - |
| 3.4.21.26 | trypomastigote | high enzyme expression | Trypanosoma cruzi | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | collagens + H2O | in host extracellular matrix | Trypanosoma cruzi | ? | - |
? | |
| 3.4.21.26 | collagens + H2O | mammalian substrate | Trypanosoma cruzi | ? | - |
? | |
| 3.4.21.26 | Fibronectin + H2O | in host extracellular matrix | Trypanosoma cruzi | ? | - |
? | |
| 3.4.21.26 | Fibronectin + H2O | mammalian substrate | Trypanosoma cruzi | ? | - |
? | |
| 3.4.21.26 | gliadins + H2O | in host gut | Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | gliadins + H2O | mammalian substrate | Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | enzyme inhibitors are able to prevent the in vitro invasion of rodent muscle cells by trypomastigotes | Trypanosoma cruzi | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme induces cleavage of gluten-derived peptides predigested by pepsin and pancreatic enzymes an exhibiting a detoxifying effect in the host's gut | Elizabethkingia meningoseptica | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition also positively affects neurodiseases, overview | Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition can improve the retention time when administered before either the acquisition or the retential trial in scopolamine-induced amnesia, enzyme inhibition positively affects neurodiseases, overview | Mus musculus | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is involved in the phosphoinositide pathway, in formation and processing of amyloid beta-peptide, protein secretion, and in neuronal differentiation and maturation, overview, the enzyme is involved in several diseases, e.g. celiac disease, Alzheimer's diease, Parkinsons's disease, affective disorders, eating disorders, cancer, inflammation, hypertension, and neurodegenarative disorders, overview, enzyme inhibition positively affects neurodiseases, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme shows endopeptidase activity with peptides no longer than 3 amino acids | Mus musculus | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme shows endopeptidase activity with peptides no longer than 3 amino acids | Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme shows endopeptidase activity with peptides no longer than 30 amino acids | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | ? | x * 78000, about, sequence determination | Trypanosoma cruzi |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | POP | - |
Mus musculus |
| 3.4.21.26 | POP | - |
Homo sapiens |
| 3.4.21.26 | POP | - |
Rattus norvegicus |
| 3.4.21.26 | POP | - |
Elizabethkingia meningoseptica |
| 3.4.21.26 | POP Tc80 | - |
Trypanosoma cruzi |
| 3.4.21.26 | post-proline cleaving enzyme | - |
Mus musculus |
| 3.4.21.26 | post-proline cleaving enzyme | - |
Homo sapiens |
| 3.4.21.26 | post-proline cleaving enzyme | - |
Rattus norvegicus |
| 3.4.21.26 | post-proline cleaving enzyme | - |
Trypanosoma cruzi |
| 3.4.21.26 | post-proline cleaving enzyme | - |
Elizabethkingia meningoseptica |
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