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Literature summary extracted from

  • Korpi, J.T.; Kervinen, V.; Maeklin, H.; Vaeaenaenen, A.; Lahtinen, M.; Laeaerae, E.; Ristimaeki, A.; Thomas, G.; Ylipalosaari, M.; Astroem, P.; Lopez-Otin, C.; Sorsa, T.; Kantola, S.; Pirilae, E.; Salo, T.
    Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer (2008), Br. J. Cancer, 98, 766-775.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.34 additional information the enzyme expression is induced by estrogen Mus musculus
3.4.24.34 additional information the enzyme expression is induced by estrogen Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.34 additional information construction of MMP-8 knockout mice by gene targeting, MMP-8-deficient female mice develop tongue squamous cell carcinoma at a significantly higher incidence than wild-type mice exposed to carcinogen 4-nitroquinoline-N-oxide, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.34 GM6001 an MMP inhibitor Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.34 Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.34 Collagen + H2O Mus musculus
-
 ?
-
 ?
3.4.24.34 Collagen + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.34 estrogen receptor alpha + H2O Mus musculus
-
 ?
-
 ?
3.4.24.34 estrogen receptor alpha + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.34 estrogen receptor beta + H2O Mus musculus
-
 ?
-
 ?
3.4.24.34 estrogen receptor beta + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.34 additional information Mus musculus expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview ?
-
 ?
3.4.24.34 additional information Homo sapiens expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.34 Homo sapiens
-
-
-
3.4.24.34 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.34 HSC-3 cell
-
 Homo sapiens
-
3.4.24.34 OSCC cell
-
 Homo sapiens
-
3.4.24.34 squamous cell carcinoma cell induced by 4-nitroquinoline N-oxide Mus musculus
-
3.4.24.34 squamous cell carcinoma cell induced by 4-nitroquinoline N-oxide Homo sapiens
-
3.4.24.34 tongue
-
 Mus musculus
-
3.4.24.34 tongue
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.34 Collagen + H2O
-
 Mus musculus ?
-
 ?
3.4.24.34 Collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.34 estrogen receptor alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.34 estrogen receptor alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.34 estrogen receptor beta + H2O
-
 Mus musculus ?
-
 ?
3.4.24.34 estrogen receptor beta + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.34 additional information expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview Mus musculus ?
-
 ?
3.4.24.34 additional information expression of MMP-8 is positively associated with improved survival of the patients suffering squamous cell carcinoma of the tongue and the tendency is particularly prominent in females, MMP-8 has a protective, probably estrogen-related, role in mobile tongue carcinoma, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.34 collagenase-2
-
 Mus musculus
3.4.24.34 collagenase-2
-
 Homo sapiens
3.4.24.34 Matrix metalloproteinase-8
-
 Mus musculus
3.4.24.34 Matrix metalloproteinase-8
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.34 37
-
 assay at Mus musculus
3.4.24.34 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.34 7.4
-
 assay at Mus musculus
3.4.24.34 7.4
-
 assay at Homo sapiens