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Literature summary extracted from

  • Daubie, V.; Cauwenberghs, S.; Senden, N.H.; Pochet, R.; Lindhout, T.; Buurman, W.A.; Heemskerk, J.W.
    Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation (2006), Biochim. Biophys. Acta, 1763, 860-869.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.6 additional information no activation of CA2+ responses by tissue factor TF or factor VIIa Homo sapiens
3.4.21.6 additional information no activation of CA2+ responses by tissue factor TF or factor VIIa Bos taurus
3.4.21.6 Phospholipids
-
 Homo sapiens
3.4.21.6 Phospholipids
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.6 antithrombin complete inhibition Bos taurus
3.4.21.6 antithrombin complete inhibition Homo sapiens
3.4.21.6 DEGR-chloromethyl ketone inactivation Bos taurus
3.4.21.6 DEGR-chloromethyl ketone inactivation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.6 extracellular
-
 Homo sapiens
-
-
3.4.21.6 extracellular
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.6 Ca2+ Ca2+-dependent binding of factor Xa to e.g. phospholipids Homo sapiens
3.4.21.6 Ca2+ Ca2+-dependent binding of factor Xa to e.g. phospholipids Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.6 additional information Homo sapiens factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview ?
-
 ?
3.4.21.6 additional information Bos taurus factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview ?
-
 ?
3.4.21.6 protease-activated receptor 1 + H2O Homo sapiens PAR-1 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 1 + ?
-
 ?
3.4.21.6 protease-activated receptor 1 + H2O Bos taurus PAR-1 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 1 + ?
-
 ?
3.4.21.6 protease-activated receptor 2 + H2O Homo sapiens PAR-2 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 2 + ?
-
 ?
3.4.21.6 protease-activated receptor 2 + H2O Bos taurus PAR-2 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 2 + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Bos taurus
-
-
-
3.4.21.6 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.6 proteolytic modification the factor X is activated to factor Xa by Russell's viper venom Homo sapiens
3.4.21.6 proteolytic modification the factor X is activated to factor Xa by Russell's viper venom Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.6 native factor X from plasma Homo sapiens
3.4.21.6 native factor X from plasma Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.6 plasma
-
 Homo sapiens
-
3.4.21.6 plasma
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.6 additional information
-
 measurement of Ca2+ responses, oscillatory response pattern, overview Homo sapiens
3.4.21.6 additional information
-
 measurement of Ca2+ responses, oscillatory response pattern, overview Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 additional information factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview Homo sapiens ?
-
 ?
3.4.21.6 additional information factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview Bos taurus ?
-
 ?
3.4.21.6 protease-activated receptor 1 + H2O
-
 Homo sapiens activated protease-activated receptor 1 + ?
-
 ?
3.4.21.6 protease-activated receptor 1 + H2O
-
 Bos taurus activated protease-activated receptor 1 + ?
-
 ?
3.4.21.6 protease-activated receptor 1 + H2O PAR-1 activation mediates activation of phospholipase C in endothelial cells Homo sapiens activated protease-activated receptor 1 + ?
-
 ?
3.4.21.6 protease-activated receptor 1 + H2O PAR-1 activation mediates activation of phospholipase C in endothelial cells Bos taurus activated protease-activated receptor 1 + ?
-
 ?
3.4.21.6 protease-activated receptor 2 + H2O
-
 Homo sapiens activated protease-activated receptor 2 + ?
-
 ?
3.4.21.6 protease-activated receptor 2 + H2O
-
 Bos taurus activated protease-activated receptor 2 + ?
-
 ?
3.4.21.6 protease-activated receptor 2 + H2O PAR-2 activation mediates activation of phospholipase C in endothelial cells Homo sapiens activated protease-activated receptor 2 + ?
-
 ?
3.4.21.6 protease-activated receptor 2 + H2O PAR-2 activation mediates activation of phospholipase C in endothelial cells Bos taurus activated protease-activated receptor 2 + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 factor Xa
-
 Homo sapiens
3.4.21.6 factor Xa
-
 Bos taurus