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Literature summary extracted from

  • Zou, J.; Marjanovic, J.; Kisseleva, M.V.; Wilson, M.; Majerus, P.W.
    Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis (2007), Proc. Natl. Acad. Sci. USA, 104, 16834-16839.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.78 etoposide significantly increases type I 4-phosphatase in the nuclear fraction, in both the endogenous and overexpression system Homo sapiens

Application

EC Number Application Comment Organism
3.1.3.78 medicine type I 4-phosphatase regulates nuclear phosphatidylinositol 5-phosphate levels, which in turn mediate p53-dependent apoptosis through interaction with inhibitor of growth protein-2 in response to genotoxic stress Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.78 stably transfected HEK-293 TRex cells in a tetracycline-inducible vector expressing type I and II 4-phosphatase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.78 PIPKIIbeta inhibits p53 acetylation and cell death Homo sapiens
3.1.3.78 RNAi siRNA of type I 4-phosphatase reduces type I 4-phosphatase levels, which is followed by a dramatic decrease in p53 levels in response to the genotoxic agent etoposide. siRNA of type II 4-phosphatase does not reduce p53 expression Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.78 nucleus when HeLa cells are treated with etoposide or doxorubicin, type I 4-phosphatase translocates to the nucleus and nuclear levels of phosphatidylinositol 5-phosphate increase Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.78 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.78 phosphatidylinositol-4,5-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol-5-phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.78 type I 4-phosphatase
-
 Homo sapiens
3.1.3.78 type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase
-
 Homo sapiens
3.1.3.78 type II 4-phosphatase
-
 Homo sapiens