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Literature summary extracted from

  • Suarez-Rodriguez, M.C.; Adams-Phillips, L.; Liu, Y.; Wang, H.; Su, S.H.; Jester, P.J.; Zhang, S.; Bent, A.F.; Krysan, P.J.
    MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants (2007), Plant Physiol., 143, 661-669.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.11.25 additional information may play a structural role in signaling, independent of its protein kinase activity, MEKK1 kinase activity may not be required to activate FLS2-mediated defense responses in Arabidopsis. MEKK1 acts upstream of MPK4 as a negative regulator of pathogen response pathways, a function that may not require MEKK1's full kinase activity Arabidopsis thaliana

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.25 MEKK1 and mutant K361M constructs introduced into Arabidopsis plants via Agrobacterium transformation Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.25 K361M kinase-inactive MEKK1, rescues the mekk1 dwarf penotype. Elevated temperature dramatically improves the growth of mekk1 plants. K361M plants are fully fertile and grow with a morphology closely resembling wild-type plants. When treated with pathogenic bacteria, K361M plants are slightly more susceptible to an avirulent strain of Pseudomonas syringae and show a delayed hypersensitive response Arabidopsis thaliana
2.7.11.25 additional information mekk1 knockout mutants, display a severe dwarf phenotype, constitutive callose deposition, and constitutive expression of pathogen response genes. The dwarf phenotype is largely rescued by introduction into mekk1 knockout plants of either mutant K361M or a nahG transgene that degrades salicylic acid Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Arabidopsis thaliana
-
 Columbia ecotype
-

Storage Stability

EC Number Storage Stability Organism
2.7.11.25 -80°C Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + myelin basic protein
-
 Arabidopsis thaliana ADP + phosphorylated myelin basic protein
-
 ?
2.7.11.25 additional information activity of MEKK1 may not be required for flg22-induced MPK4, MPK3 or MPK6 activation or for other macroscopic FLS2-mediated responses Arabidopsis thaliana ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 MEKK1
-
 Arabidopsis thaliana
2.7.11.25 mitogen-activated protein kinase kinase kinase
-
 Arabidopsis thaliana