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Literature summary extracted from

  • Bando, Y.; Ito, S.; Nagai, Y.; Terayama, R.; Kishibe, M.; Jiang, Y.P.; Mitrovic, B.; Takahashi, T.; Yoshida, S.
    Implications of protease M/neurosin in myelination during experimental demyelination and remyelination (2006), Neurosci. Lett., 405, 175-180.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.B10 additional information expression of protease M is increased in GST-pi-positive oligodendrocytes during remyelination. After tumor necrosis factor-alpha and IFN-gamma stimulation colocalization of protease M and myelin basic protein in the oligodendroglial process Mus musculus

Application

EC Number Application Comment Organism
3.4.21.B10 medicine protease M in oligodendrocytes is closely associated with the expression of the myelin basic protein and the PLP gene. Maintenance of myelination is an important function of protease M in oligodendrocytes. The enzyme may be related to the oligodendroglial response to myelin disorders Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B10 into pPUR-tRNA plasmid and transfected into primary oligodendrocytes Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B10 additional information expression of protease M mRNA and protein is rapidly reduced in demyelination Mus musculus
3.4.21.B10 RNAi suppression of protease M, causes a decrease in myelin basic protein mRNA in cultured oligodendrocytes Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B10 Mus musculus
-
 Balb/c mice
-
3.4.21.B10 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B10 brain
-
 Mus musculus
-
3.4.21.B10 central nervous system
-
 Mus musculus
-
3.4.21.B10 oligodendrocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B10 myelin basic protein + H2O close relationship between protease M and myelin proteins Mus musculus ?
-
 ?
3.4.21.B10 myelin basic protein + H2O close relationship between protease M and myelin proteins Mus musculus BALB/c ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B10 KLK6
-
 Mus musculus
3.4.21.B10 protease M
-
 Mus musculus