Literature summary extracted from

Martinez Molina, D.; Wetterholm, A.; Kohl, A.; McCarthy, A.A.; Niegowski, D.; Ohlson, E.; Hammarberg, T.; Eshaghi, S.; Haeggstroem, J.Z.; Nordlund, P.
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase (2007), Nature, 448, 613-616.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.4.1.20	overexpression in the yeast Pichia pastoris with a His6 tag	Homo sapiens

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
4.4.1.20	its apo and GSH-complexed forms to 2.00 and 2.15 A resolution, using the sitting drop vapour diffusion technique	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.4.1.20	Homo sapiens	Q16873	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
4.4.1.20	extraction with a Triton X-100/Triton-DOC mixture, two affinity chromatography steps and gel filtration	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.4.1.20	leukotriene A4 + glutathione	-	Homo sapiens	leukotriene C4	-	?

Subunits

EC Number	Subunits	Comment	Organism
4.4.1.20	trimer	each monomer is composed of four transmembrane segments	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
4.4.1.20	leukotriene C4 synthetase	-	Homo sapiens
4.4.1.20	LTC4 synthase	-	Homo sapiens
4.4.1.20	LTC4S	-	Homo sapiens

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Release 2023.1 (January 2023)