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Literature summary extracted from
- Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides (2007), Mol. Pharmacol., 72, 526-535.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Calmodulin | - |
Bordetella pertussis |  |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | drug development | CyaA substantially contributes to the pathogenesis of whooping cough, catalytic site of CyaA possesses substantial conformational freedom to accommodate structurally diverse ligands, certain ligands bind to CyaA even in the absence of calmodulin, facilitating future inhibitor design | Bordetella pertussis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | 2'-methylanthraniloyl-3'-d-ATP | - |
Bordetella pertussis | |
| 4.6.1.1 | 2,4,6-trinitrophenyl-ATP | - |
Bordetella pertussis | |
| 4.6.1.1 | 2,4,6-trinitrophenyl-CTP | - |
Bordetella pertussis | |
| 4.6.1.1 | 2,4,6-trinitrophenyl-GTP | - |
Bordetella pertussis | |
| 4.6.1.1 | 2,4,6-trinitrophenyl-UTP | - |
Bordetella pertussis | |
| 4.6.1.1 | 3'-methylanthraniloyl-2'-d-ATP | - |
Bordetella pertussis | |
| 4.6.1.1 | 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | - |
Bordetella pertussis | |
| 4.6.1.1 | ANT-ADP | - |
Bordetella pertussis | |
| 4.6.1.1 | ANT-ATP | - |
Bordetella pertussis | |
| 4.6.1.1 | ANT-GTP | - |
Bordetella pertussis | |
| 4.6.1.1 | anthraniloyl-ADP | - |
Bordetella pertussis | |
| 4.6.1.1 | anthraniloyl-ATP | - |
Bordetella pertussis | |
| 4.6.1.1 | anthraniloyl-GTP | - |
Bordetella pertussis | |
| 4.6.1.1 | CTP | - |
Bordetella pertussis | |
| 4.6.1.1 | di-methylanthraniloyl-IMP | - |
Bordetella pertussis | |
| 4.6.1.1 | GTP | - |
Bordetella pertussis | |
| 4.6.1.1 | ITP | - |
Bordetella pertussis | |
| 4.6.1.1 | ITPgammaS | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-ADP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-ATP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-ATPgammaS | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-CDP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-CTP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-GDP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-GTP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-GTPgammaS | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-IDP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-IMP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-ITP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-ITPgammaS | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-UDP | - |
Bordetella pertussis | |
| 4.6.1.1 | methylanthraniloyl-UTP | - |
Bordetella pertussis | |
| 4.6.1.1 | UTP | - |
Bordetella pertussis | |
| 4.6.1.1 | UTPgammaS | - |
Bordetella pertussis | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.6.1.1 | 0.045 | - |
ATP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.609 | - |
ATP | in the presence of Mg2+ | Bordetella pertussis | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Mg2+ | - |
Bordetella pertussis | |
| 4.6.1.1 | Mn2+ | - |
Bordetella pertussis | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | Bordetella pertussis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | ATP | - |
Bordetella pertussis | 3',5'-cAMP + diphosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | CyaA | - |
Bordetella pertussis |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.6.1.1 | 0.000001 | - |
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.000025 | - |
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0002 | - |
3'-methylanthraniloyl-2'-d-ATP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0003 | - |
2'-methylanthraniloyl-3'-d-ATP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0006 | - |
methylanthraniloyl-ITP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0011 | - |
methylanthraniloyl-CTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0012 | - |
methylanthraniloyl-ATPgammaS | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0013 | - |
anthraniloyl-ATP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0018 | - |
methylanthraniloyl-ITPgammaS | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0026 | - |
methylanthraniloyl-UTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0043 | - |
methylanthraniloyl-ATP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0054 | - |
methylanthraniloyl-GTPgammaS | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0059 | - |
methylanthraniloyl-GTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0065 | - |
2,4,6-trinitrophenyl-ATP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.0074 | - |
methylanthraniloyl-GTPgammaS | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.01 | - |
2,4,6-trinitrophenyl-CTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.011 | - |
methylanthraniloyl-IDP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.011 | - |
anthraniloyl-ADP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.012 | - |
methylanthraniloyl-ADP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.015 | - |
methylanthraniloyl-ATPgammaS | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.016 | - |
methylanthraniloyl-ITP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.016 | - |
methylanthraniloyl-GTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.018 | - |
methylanthraniloyl-CDP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.02 | - |
anthraniloyl-ATP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.02 | - |
2,4,6-trinitrophenyl-GTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.02 | - |
di-methylanthraniloyl-IMP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.022 | - |
2'-methylanthraniloyl-3'-d-ATP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.027 | - |
GTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.029 | - |
anthraniloyl-GTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.031 | - |
methylanthraniloyl-ITPgammaS | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.032 | - |
3'-methylanthraniloyl-2'-d-ATP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.035 | - |
CTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.036 | - |
methylanthraniloyl-CTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.036 | - |
UTPgammaS | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.037 | - |
di-methylanthraniloyl-IMP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.042 | - |
methylanthraniloyl-UTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.043 | - |
methylanthraniloyl-UDP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.051 | - |
methylanthraniloyl-ATP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.058 | - |
2,4,6-trinitrophenyl-UTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.06 | - |
methylanthraniloyl-GDP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.077 | - |
ITPgammaS | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.091 | - |
methylanthraniloyl-ADP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
methylanthraniloyl-IDP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
methylanthraniloyl-IMP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
methylanthraniloyl-CDP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
methylanthraniloyl-UDP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
anthraniloyl-GTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
anthraniloyl-ADP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
ITP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.1 | - |
methylanthraniloyl-IMP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.11 | - |
2,4,6-trinitrophenyl-ATP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.12 | - |
UTP | in the presence of Mn2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.26 | - |
GTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.27 | - |
CTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.32 | - |
2,4,6-trinitrophenyl-GTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.33 | - |
UTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.41 | - |
2,4,6-trinitrophenyl-CTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 0.78 | - |
2,4,6-trinitrophenyl-UTP | in the presence of Mg2+ | Bordetella pertussis | |
| 4.6.1.1 | 1.1 | - |
ITP | in the presence of Mg2+ | Bordetella pertussis | |
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