Literature summary extracted from

Strik, M.C.; de Koning, P.J.; Kleijmeer, M.J.; Bladergroen, B.A.; Wolbink, A.M.; Griffith, J.M.; Wouters, D.; Fukuoka, Y.; Schwartz, L.B.; Hack, C.E.; van Ham, S.M.; Kummer, J.A.
Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation (2007), Mol. Immunol., 44, 3462-3472.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.79	A23187	induces granzyme B expression in mast cell lines HMC-1 and LAD2 and cord blood-derived mast cells	Homo sapiens
3.4.21.79	compound 48/80	induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells	Homo sapiens
3.4.21.79	additional information	mature skin-derived mast cells only produce granzyme B upon IgE-dependent stimulation by FcepsilonRI	Homo sapiens
3.4.21.79	PMA	stimulates	Homo sapiens
3.4.21.79	SERPINB9	-	Homo sapiens
3.4.21.79	Substance P	induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells	Homo sapiens

Application

EC Number	Application	Comment	Organism
3.4.21.79	additional information	role for granzyme B as mediator in mast cell biology	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.79	cytoplasm	active in cytoplasmic granules, mainly located in the dense core, partially colocalizes with tryptase in granules with both lysosomal and secretory features	Homo sapiens	5737	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.79	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.79	colon	between smooth muscle cells	Homo sapiens	-
3.4.21.79	mast cell	cord blood- and mature skin-derived mast cells. Majority of lesional mast cells express abundant GrB	Homo sapiens	-
3.4.21.79	additional information	unstimulted HMC-1 cells and LAD 2 cells show no Grb mRNA and protein, expression upon stimulation with non-physiological stimuli	Homo sapiens	-
3.4.21.79	skin	around skin appendages	Homo sapiens	-
3.4.21.79	tonsil	around small vessels	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.79	acetyl-Ile-Glu-Thr-Asp-p-nitroanilide + H2O	-	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.79	cytotoxic lymphocyte-associated protease	-	Homo sapiens
3.4.21.79	cytotoxic lymphocyte-specific protein	-	Homo sapiens
3.4.21.79	GrB	-	Homo sapiens

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Release 2023.1 (January 2023)