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Literature summary extracted from

  • Mast, S.W.; Moremen, K.W.
    Family 47 alpha-mannosidases in N-glycan processing (2006), Methods Enzymol., 415, 31-46.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.113 expressed in Pichia pastoris Mus musculus
3.2.1.209 expressed in Pichia pastoris Homo sapiens
3.2.1.209 expressed in Pichia pastoris Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.209 D463N binding affinity Homo sapiens
3.2.1.209 E330Q catalytic mutant, contributes to general acid function Homo sapiens
3.2.1.209 E599Q general base Homo sapiens
3.2.1.209 F659A glycone binding affinity, catalysis Homo sapiens
3.2.1.209 R461A minor contribution to catalysis, glycan binding affinity Homo sapiens
3.2.1.209 R461L branch specificity/steric hindrance Homo sapiens
3.2.1.209 R597A minor contribution to catalysis Homo sapiens
3.2.1.209 T688A Ca2+ tethering, catalysis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.209 1-deoxymannojirimycin
-
 Homo sapiens
3.2.1.209 kifunensine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.113 Golgi apparatus
-
 Mus musculus 5794
-
3.2.1.209 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.2.1.209 endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.113 Mus musculus P45700
-
-
3.2.1.209 Homo sapiens Q9UKM7
-
-
3.2.1.209 Saccharomyces cerevisiae P32906
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.113 glycoprotein
-
 Mus musculus
3.2.1.209 glycoprotein
-
 Saccharomyces cerevisiae

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.113
-
 Mus musculus
3.2.1.209
-
 Homo sapiens
3.2.1.209
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.113 alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O
-
 Mus musculus alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O
-
 Homo sapiens alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O
-
 Saccharomyces cerevisiae alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.113 alpha-mannosidase Class 1 mannosidases, CAZy GH family 47 Mus musculus
3.2.1.113 GolgiManI
-
 Mus musculus
3.2.1.209 alpha-mannosidase Class 1 mannosidases, CAZy GH family 47 Homo sapiens
3.2.1.209 alpha-mannosidase Class 1 mannosidases, CAZy GH family 47 Saccharomyces cerevisiae
3.2.1.209 ERManI
-
 Homo sapiens
3.2.1.209 ERManI
-
 Saccharomyces cerevisiae