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Literature summary extracted from

  • Park, C.H.; Nguyen, S.D.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
    Differential effect of lysophospholipids on activities of human plasma paraoxonase1, either soluble or lipid-bound (2006), Lipids, 41, 371-380.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.2 lysophosphatidylinositol 0.01 mM, 10% stimulation of arylesterase activity Homo sapiens
3.1.1.2 monooleoyl-lysophosphatidylserine 0.01 mM, 8% stimulation of arylesterase activity Homo sapiens
3.1.1.2 palmitoyl-lysophosphatidylglycerol 0.01 mM, 47% stimulation of arylesterase activity Homo sapiens
3.1.8.1 palmitoyl-lysophosphatidylglycerol 0.01 mM, 14% stimulation of paraoxonase, 40% stimulation of diazoxonase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.8.1 1-myristoyl-lysophosphatidylglycerol selective, noncompetitive inhibition of paraoxonase activity Homo sapiens
3.1.8.1 1-palmitoyl-lysophosphatidylglycerol selective, noncompetitive inhibition of paraoxonase activity, charge interactions, inhibition is almost completely suppressed by 1 M NaCl Homo sapiens
3.1.8.1 1-stearoyl-lysophosphatidylglycerol selective, noncompetitive inhibition of paraoxonase activity Homo sapiens
3.1.8.1 lysophosphatidylinositol inhibition of paraoxonase Homo sapiens
3.1.8.1 additional information differential effect of lysophospholipids on activities of native PON1 as well as of high-density lipoprotein or dimyristoylphosphatidylcholine-bound PON1, kinetics, overview Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.2 1.42
-
 paraoxon pH 7.4, 25°C Homo sapiens
3.1.8.1 1.42
-
 paraoxon pH 7.4, 25°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.2 blood plasma
-
 Homo sapiens
-
3.1.8.1 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 4-nitrophenyl diethylphosphate + H2O
-
 Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.8.1 diazoxon + H2O
-
 Homo sapiens ?
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens 4-nitrophenol + diethyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 paraoxonase 1
-
 Homo sapiens
3.1.8.1 PON1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.2 37
-
 assay at Homo sapiens
3.1.8.1 25
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.8.1 3400
-
 paraoxon pH 8.0, 30°C Brevundimonas diminuta

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.2 7.4
-
 assay at Homo sapiens
3.1.8.1 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.8.1 0.041
-
 palmitoyl-lysophosphatidylglycerol pH 7.4, 25°C Homo sapiens