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Literature summary extracted from

  • Hashimotodani, Y.; Ohno-Shosaku, T.; Kano, M.
    Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus (2007), J. Neurosci., 27, 1211-1219.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 6-methyl-2-p-tolylamino-benzo[d] [1,3]oxazin-4-one i.e. URB754 Mus musculus
3.1.1.23 6-methyl-2-p-tolylamino-benzo[d] [1,3]oxazin-4-one i.e. URB754 Rattus norvegicus
3.1.1.23 arachidonoyl trifluoromethylketone causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview Mus musculus
3.1.1.23 arachidonoyl trifluoromethylketone causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview Rattus norvegicus
3.1.1.23 arachidonoyltrifluoromethyl ketone i.e. ATFMK, inhibition is reversible by AM281 Mus musculus
3.1.1.23 arachidonoyltrifluoromethyl ketone i.e. ATFMK, inhibition is reversible by AM281 Rattus norvegicus
3.1.1.23 meloxicam
-
 Mus musculus
3.1.1.23 meloxicam
-
 Rattus norvegicus
3.1.1.23 methyl arachidonyl fluorophosphonate causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview; i.e. MAFP Mus musculus
3.1.1.23 methyl arachidonyl fluorophosphonate causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview; i.e. MAFP Rattus norvegicus
3.1.1.23 additional information inhibitors of other endocannabinoid hydrolyzing enzymes, fatty acid amide hydrolase and cyclooxygenase-2, have no effect on the 2-AG-induced IPSC suppression Mus musculus
3.1.1.23 additional information inhibitors of other endocannabinoid hydrolyzing enzymes, fatty acid amide hydrolase and cyclooxygenase-2, have no effect on the 2-AG-induced IPSC suppression Rattus norvegicus
3.1.1.23 tetrahydrolipstatin
-
 Mus musculus
3.1.1.23 tetrahydrolipstatin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.23 axon presynaptic enzyme Mus musculus 30424
-
3.1.1.23 axon presynaptic enzyme Rattus norvegicus 30424
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O Mus musculus presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O Rattus norvegicus presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O Mus musculus C57BL/6 presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus glycerol + arachidonic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Mus musculus
-
 C57BL/6 mice
-
3.1.1.23 Mus musculus C57BL/6
-
 C57BL/6 mice
-
3.1.1.23 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 hippocampus
-
 Mus musculus
-
3.1.1.23 hippocampus
-
 Rattus norvegicus
-
3.1.1.23 neuron
-
 Mus musculus
-
3.1.1.23 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Mus musculus glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Rattus norvegicus glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus Mus musculus glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus Rattus norvegicus glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Mus musculus C57BL/6 glycerol + arachidonic acid
-
 ?
3.1.1.23 2-arachidonoylglycerol + H2O presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus Mus musculus C57BL/6 glycerol + arachidonic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 monoacylglycerol lipase
-
 Mus musculus
3.1.1.23 monoacylglycerol lipase
-
 Rattus norvegicus