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Literature summary extracted from

  • Liu, T.; Kapustin, G.; Etzkorn, F.A.
    Design and synthesis of a potent histone deacetylase inhibitor (2007), J. Med. Chem., 50, 2003-2006.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 (2S)-2-(acetylamino)-3-[3-[(2S)-2-[[(2S)-2-ammonio-7-(hydroxyamino)-7-oxoheptanoyl]amino]-3-methoxy-3-oxopropyl]phenyl]propanoate
-
 Homo sapiens
3.5.1.98 methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate tight binding competitive inhibition Homo sapiens
3.5.1.98 methyl N-[(2S)-2-[(N-acetyl-L-alanyl)amino]-7-(hydroxyamino)-7-oxoheptanoyl]-L-phenylalaninate
-
 Homo sapiens
3.5.1.98 suberoylanilide hydroxamic acid
-
 Homo sapiens
3.5.1.98 trichostatin A
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 HeLa cell
-
 Homo sapiens
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.98 0.0000137
-
 methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate HeLa cell nuclear extract Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.98 0.00004
-
 isoform HDAC8 Homo sapiens trichostatin A
3.5.1.98 0.000041
-
 HeLa cell nuclear extract Homo sapiens trichostatin A
3.5.1.98 0.000046
-
 HeLa cell nuclear extract Homo sapiens methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate
3.5.1.98 0.000057
-
 isoform HDAC1 Homo sapiens methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate
3.5.1.98 0.00006
-
 isoform HDAC1 Homo sapiens trichostatin A
3.5.1.98 0.00011
-
 HeLa cell nuclear extract Homo sapiens suberoylanilide hydroxamic acid
3.5.1.98 0.000112
-
 isoform HDAC1 Homo sapiens suberoylanilide hydroxamic acid
3.5.1.98 0.000167
-
 HeLa cell nuclear extract Homo sapiens methyl N-[(2S)-2-[(N-acetyl-L-alanyl)amino]-7-(hydroxyamino)-7-oxoheptanoyl]-L-phenylalaninate
3.5.1.98 0.000174
-
 isoform HDAC1 Homo sapiens methyl N-[(2S)-2-[(N-acetyl-L-alanyl)amino]-7-(hydroxyamino)-7-oxoheptanoyl]-L-phenylalaninate
3.5.1.98 0.00027
-
 isoform HDAC8 Homo sapiens suberoylanilide hydroxamic acid
3.5.1.98 0.231
-
 isoform HDAC8 Homo sapiens methyl (3R,6R,9R)-9-(acetylamino)-6-[6-(hydroxyamino)-6-oxohexyl]-5,8-dioxo-4,7-diazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3-carboxylate
3.5.1.98 4
-
 isoform HDAC1 Homo sapiens (2S)-2-(acetylamino)-3-[3-[(2S)-2-[[(2S)-2-ammonio-7-(hydroxyamino)-7-oxoheptanoyl]amino]-3-methoxy-3-oxopropyl]phenyl]propanoate
3.5.1.98 8.1
-
 HeLa cell nuclear extract Homo sapiens (2S)-2-(acetylamino)-3-[3-[(2S)-2-[[(2S)-2-ammonio-7-(hydroxyamino)-7-oxoheptanoyl]amino]-3-methoxy-3-oxopropyl]phenyl]propanoate