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Literature summary extracted from

  • Ng, C.K.; Obando, D.; Widmer, F.; Wright, L.C.; Sorrell, T.C.; Jolliffe, K.A.
    Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts (2006), J. Med. Chem., 49, 811-816.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.5 medicine cryptococcal phospholipase B1 is a virulence factor Cryptococcus neoformans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.5 1,12-bis(tributylammonium)dodecane
-
 Cryptococcus neoformans
3.1.1.5 1,12-bis(trihexylammonium)dodecane
-
 Cryptococcus neoformans
3.1.1.5 1,12-bis(triisopentylammonium)dodecane
-
 Cryptococcus neoformans
3.1.1.5 1,12-bis(tripentylammonium)dodecane
-
 Cryptococcus neoformans
3.1.1.5 1,12-bis(tripropylammonium)dodecane
-
 Cryptococcus neoformans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.5 extracellular
-
 Cryptococcus neoformans
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.5 Cryptococcus neoformans
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.5 PLB1
-
 Cryptococcus neoformans

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.5 0.0035
-
-
 Cryptococcus neoformans 1,12-bis(tripentylammonium)dodecane
3.1.1.5 0.007
-
-
 Cryptococcus neoformans 1,12-bis(tripropylammonium)dodecane
3.1.1.5 0.0075
-
-
 Cryptococcus neoformans 1,12-bis(triisopentylammonium)dodecane
3.1.1.5 0.0075
-
-
 Cryptococcus neoformans 1,12-bis(trihexylammonium)dodecane
3.1.1.5 0.01
-
-
 Cryptococcus neoformans 1,12-bis(tributylammonium)dodecane