Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Clarenbach, J.J.; Vega, G.L.; Adams-Huet, B.; Considine, R.V.; Ricks, M.; Sumner, A.E.
    Variability in postheparin hepatic lipase activity is associated with plasma adiponectin levels in African Americans (2007), J. Investig. Med., 55, 187-194.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.3 0.038
-
 1,2-didecanoyl-1-thioglycerol 37°C, pH 7.4 Bos taurus
3.1.1.3 0.055
-
 1-stearoyl-2-arachidonoyl-sn-glycerol 37°C, pH 7.4 Bos taurus
3.1.1.3 0.063
-
 1-stearoyl-2-arachidonoyl-sn-glycerol 37°C, pH 7.4 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.3 microsome
-
 Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.3 27000
-
 x * 27000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.3 additional information Bos taurus diacylglycerol lipase may regulate protein kinase C activity and 2-arachidonoyl-sn-glycerol levels by rapidly altering the intracellular concentration of diacylglycerols ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.3 Bos taurus Q2KI18
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.3 phosphoprotein phosphorylation by cAMP-dependent protein kinase results in a three-fold increase in catalytic thrpoughput Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.3
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.3 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.3 1,2-didecanoyl-1-thioglycerol + H2O
-
 Bos taurus ?
-
 ?
3.1.1.3 1-stearoyl-2-arachidonoyl-sn-glycerol + H2O
-
 Bos taurus ?
-
 ?
3.1.1.3 additional information diacylglycerol lipase may regulate protein kinase C activity and 2-arachidonoyl-sn-glycerol levels by rapidly altering the intracellular concentration of diacylglycerols Bos taurus ?
-
 ?
3.1.1.3 additional information 1,2-diacyl-sn-glycerols are the preferred substrates over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1-position of 1,2-diacyl-sn-glycerols. 1-O-alkyl-2-acyl-sn-glycerols are not a substrate for the enzyme Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.3 ? x * 27000, SDS-PAGE Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.1.1.3 diacylglycerol lipase
-
 Bos taurus