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Literature summary extracted from

  • Iyer, S.S.; Agrawal, R.S.; Thompson, C.R.; Thompson, S.; Barton, J.A.; Kusner, D.J.
    Phospholipase D1 regulates phagocyte adhesion (2006), J. Immunol., 176, 3686-3696.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Collagen adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity Homo sapiens
3.1.4.4 fibronectin adhesion of primary neutrophils and monocyte-derived macrohages as well as myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity Homo sapiens
3.1.4.4 additional information adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 additional information depletion of enzyme by siRNA in macrophages results in significant inhibition of phagocyte adhesion and is accompanied by reductions in total cellular F-actin Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 additional information enzyme exhibits partial co-localization with actin filaments at the adherent interface in proximity to paxilin protein Homo sapiens
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Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 macrophage adhesion of primary neutrophils and monocyte-derived macrohages to fibronectin is accompanied by marked stimulation of enzyme activity. Similarly, adhesion of myeloid-macrophage cell lines to fibronectin, collagen, or plastic results in significant activation. Stimulation of enzyme is rapid and persists for at least 90 min Homo sapiens
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