EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.4 | Collagen | adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity | Homo sapiens | |
3.1.4.4 | fibronectin | adhesion of primary neutrophils and monocyte-derived macrohages as well as myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity | Homo sapiens | |
3.1.4.4 | additional information | adhesion of myeloid-macrophage cell lines to fibronectin is accompanied by marked stimulation of enzyme activity | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.4.4 | additional information | depletion of enzyme by siRNA in macrophages results in significant inhibition of phagocyte adhesion and is accompanied by reductions in total cellular F-actin | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.4 | additional information | enzyme exhibits partial co-localization with actin filaments at the adherent interface in proximity to paxilin protein | Homo sapiens | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.4 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.4.4 | macrophage | adhesion of primary neutrophils and monocyte-derived macrohages to fibronectin is accompanied by marked stimulation of enzyme activity. Similarly, adhesion of myeloid-macrophage cell lines to fibronectin, collagen, or plastic results in significant activation. Stimulation of enzyme is rapid and persists for at least 90 min | Homo sapiens | - |