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Literature summary extracted from

  • Renault, F.; Chabriere, E.; Andrieu, J.; Dublet, B.; Masson, P.; Rochu, D.
    Tandem purification of two HDL-associated partner proteins in human plasma, paraoxonase (PON1) and phosphate binding protein (HPBP) using hydroxyapatite chromatography (2006), J. Chromatogr. B, 836, 15-21.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.2 Ca2+ required Homo sapiens
3.1.8.1 Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.2 additional information Homo sapiens PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein ?
-
 ?
3.1.8.1 additional information Homo sapiens PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.2 co-purification of PON1 and phosphate binding protein from high-density-lipoprotein-particles using hydroxyapatite chromatography, method development Homo sapiens
3.1.8.1 co-purification of PON1 and phosphate binding protein from high-density-lipoprotein-particles using hydroxyapatite chromatography, method development Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein Homo sapiens ?
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.8.1 additional information PON1 hydrolyses esters, including organophosphates and lactones, and exhibits anti-atherogenic properties, the enzyme is associated to high-density-lipoprotein, bound together with the human phosphate binding protein Homo sapiens ?
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens 4-nitrophenol + diethyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.8.1 PON1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.2 25
-
 assay at Homo sapiens
3.1.8.1 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.2 8
-
 assay at Homo sapiens
3.1.8.1 10.5
-
 assay at Homo sapiens