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Literature summary extracted from

  • Wolf, M.; Nunes, F.; Henkel, A.; Heinick, A.; Paul, R.J.
    The MAP kinase JNK-1 of Caenorhabditis elegans: Location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness (2007), J. Cell. Physiol., 214, 721-729.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information JNK-1 is activated by phosphorylation, ambient temperature of 1-37°C specifically influences the activation/phosphorylation of the MAPkinase JNK-1 Caenorhabditis elegans

Application

EC Number Application Comment Organism
2.7.11.24 additional information indirect interactions between neuronal MAPK and peripheral insulin-like signaling in response to environmental stimuli (temperature, H2O2) Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.24 additional information transgenic jnk-1 deletion mutant, exhibits a reduced thermal tolerance and reproductive fitness at higher temperatures Caenorhabditis elegans
2.7.11.24 additional information construction of a JNK-1 deletion mutant expressing daf-16-GFP, the mutant exhibits a reduced thermal tolerance and reproductive fitness at higher temperatures compared to the wild-type enzyme, jnk-1 overexpression leads to enhanced translocation of DAF-16 Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 additional information Caenorhabditis elegans promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene sod-3, encoding superoxide dismutase 3, expressions within peripheral, non-neuronal tissue, JNK-1 modulates the intestinal stress-induced translocation of DAF-16 from the cytosol into the cell nucleus. JNK-1 is controlled by the MAPK JKK-1 under heat stress ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Caenorhabditis elegans
-
-
-
2.7.11.24 Caenorhabditis elegans Q8WQG9 several strains
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.24 phosphoprotein JNK-1 is activated by phosphorylation, ambient temperature of 1-37°C specifically influences the activation/phosphorylation of the MAPkinase JNK-1 Caenorhabditis elegans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 nerve nerve ring Caenorhabditis elegans
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2.7.11.24 neuronal cell activated JNK-1 observed only in neuronal cells Caenorhabditis elegans
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2.7.11.24 neuronal cell JNK-1 is specific for neuronal cells Caenorhabditis elegans
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 additional information promoting influence of JNK-1 on both nuclear DAF-16 translocations and DAF-16 target gene sod-3, encoding superoxide dismutase 3, expressions within peripheral, non-neuronal tissue, JNK-1 modulates the intestinal stress-induced translocation of DAF-16 from the cytosol into the cell nucleus. JNK-1 is controlled by the MAPK JKK-1 under heat stress Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 JNK-1
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 Caenorhabditis elegans
2.7.11.24 MAP kinase
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 Caenorhabditis elegans
2.7.11.24 MAPK
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 Caenorhabditis elegans
2.7.11.24 mitogen-activated protein kinase
-
 Caenorhabditis elegans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.24 additional information
-
 ambient temperature of 1-37°C specifically influences the activation/phosphorylation of the MAPkinase JNK-1 Caenorhabditis elegans
2.7.11.24 15 20 rise of degree of phosphorylation of isoforms JNK-1alpha and JNK-1beta Caenorhabditis elegans

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.7.11.24 1 37 degree of phosphorylation of isoforms JNK-1alpha and JNK-1beta increase with ambient temperature Caenorhabditis elegans