EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.21.79 | additional information | role for granzyme B in the dismantling of the cytoskeleton. In the execution phase of apoptosis it may modify key structural proteins thus enabling the cell to be properly dismantled and eliminated by phagocytosis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.79 | EGTA | inhibits granular granzyme B-mediated killing | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.79 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.79 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.79 | additional information | YT-Indy cell line | Homo sapiens | - |
3.4.21.79 | natural killer cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.79 | alpha-tubulin + H2O | alpha-tubulin derived from HeLa S100 extracts or Jurkat S100 extracts is cleaved by grB in a caspase-independent manner. Cleavage occurs at D438. Polymerized and soluble alpha-tubulin can be cleaved | Homo sapiens | truncated alpha-tubulin | - |
? | |
3.4.21.79 | pro-caspase-3 + H2O | - |
Homo sapiens | caspase-3 + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.79 | GrB | - |
Homo sapiens |