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Literature summary extracted from
- Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates (2008), J. Biol. Chem., 283, 9523-9530.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.6.4 | expression in MCF-7 cells. Following overexpression of the enzyme, total sulfated glycosaminoglycans, chondroitin 4-sulfate, and chondroitin sulfates decline significantly | Homo sapiens |
| 3.1.6.12 | expression in MCF-7 cells | Homo sapiens |
| 3.1.6.12 | expression in MCF-7 cells. Following overexpression of the enzyme, total sulfated glycosaminoglycans, chondroitin 4-sulfate, and chondroitin sulfates declines significantly | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.6.4 | lysosome | - |
Homo sapiens | 5764 | - |
| 3.1.6.12 | lysosome | - |
Homo sapiens | 5764 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.6.4 | Homo sapiens | P34059 | - |
- |
| 3.1.6.12 | Homo sapiens | P15848 | - |
- |
| 3.1.6.12 | Homo sapiens | P15848 | precursor | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.6.12 | 4-methylumbelliferyl sulfate + H2O | - |
Homo sapiens | 4-methylumbelliferone + sulfate | - |
? |  |
| 3.1.6.12 | 4-methylumbelliferyl sulfate + H2O | - |
Homo sapiens | sulfate + 4-methylumbelliferone | - |
? | |
| 3.1.6.12 | chondroitin 4-sulfate + H2O | - |
Homo sapiens | chondroitin + sulfate | - |
? | |
| 3.1.6.12 | chondroitin sulfate + H2O | - |
Homo sapiens | chondroitin + sulfate | - |
? | |
| 3.1.6.12 | dermatan sulfate + H2O | - |
Homo sapiens | dermatan + sulfate | - |
? | |
| 3.1.6.12 | sulfated glycosaminoglycan + H2O | - |
Homo sapiens | glycosaminoglycan + sulfate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.6.4 | GALNS | - |
Homo sapiens |
| 3.1.6.12 | arylsulfatase B | - |
Homo sapiens |
| 3.1.6.12 | ASB | - |
Homo sapiens |
| 3.1.6.12 | N-acetylgalactosamine-4-sulfatase | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.6.4 | 5.6 | - |
assay at | Homo sapiens |
| 3.1.6.12 | 5.6 | - |
assay at | Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.5.1.5 | malfunction | mucopolysaccharidose, upon silencing significant increase of sulfated substrates, due to overexpression significant decline of all substrates and up-regulation of chondroitin sulfate-containing proteoglycan (syndecan-1 and decorin) expression, increase of soluble syndecan-1 protein | Homo sapiens |
| 3.1.6.4 | malfunction | deficiencies of N-acetylgalactosamine-6-sulfatase is associated with the mucopolysaccharidoses | Homo sapiens |
| 3.1.6.4 | metabolism | modification of expression of the enzyme regulates the content of chondroitin sulfate | Homo sapiens |
| 3.1.6.12 | malfunction | deficiencies of N-acetylgalactosamine-4-sulfatase is associated with the mucopolysaccharidoses | Homo sapiens |
| 3.1.6.12 | metabolism | modification of expression of the enzyme regulates the content of chondroitin sulfate | Homo sapiens |
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