Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lemieux, G.A.; Blumenkron, F.; Yeung, N.; Zhou, P.; Williams, J.; Grammer, A.C.; Petrovich, R.; Lipsky, P.E.; Moss, M.L.; Werb, Z.
    The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10 (2007), J. Biol. Chem., 282, 14836-14844.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.81 additional information not stimulated by sphingosine 1-phosphate Homo sapiens

Application

EC Number Application Comment Organism
3.4.24.81 medicine potential therapeutic target for the treatment of allergic diseases Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.81 expressed in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.81 E385A inactive Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.81 GM6001 inhibits 50-60% of CD23 shedding Homo sapiens
3.4.24.81 TAPI-2 inhibits 70% of CD23 shedding Homo sapiens
3.4.24.81 TIMP-1 modest inhibitory activity toward CD23 shedding Homo sapiens
3.4.24.81 TIMP-2 modest inhibitory activity toward CD23 shedding Homo sapiens
3.4.24.81 TIMP-3 modest inhibitory activity toward CD23 shedding Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.81 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.81 2,4-dinitrophenyl-EVHHQKLVFFAE + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.81 2,4-dinitrophenyl-HGDQMAQKSQST + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.81 2,4-dinitrophenyl-LPQLENVKGTED + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.81 2,4-dinitrophenyl-RAEQQRLKSQDL + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.81 2,4-dinitrophenyl-SPLAQAVRSSSR + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.81 CD23 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.81 dabcyl-LAQA(homoPhe)RSC(fluorescein)-NH2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.81 a disintegrin and metalloproteinase 10
-
 Homo sapiens
3.4.24.81 ADAM10
-
 Homo sapiens