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Literature summary extracted from

  • Oshiro, J.; Han, G.S.; Iwanyshyn, W.M.; Conover, K.; Carman, G.M.
    Regulation of the yeast DPP1-encoded diacylglycerol pyrophosphate phosphatase by transcription factor Gis1p (2003), J. Biol. Chem., 278, 31495-31503.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.75 gene DPP1, subcloning in Escherichia coli strain DH5alpha, expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3), promoter structure determination and analysis, identification of three binding sites, URSPDS, for transcription factor Gis1p in the DPP1 promoter, direct interaction between Gis1p and DPP1 promoter elements, analysis of genetic regulation, overview Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.75 additional information construction of a mutant by deletions from the 5' end of the promoter indicated sequences responsible for enzyme expression, mutations in the three URSPDS elements within the DPP1 promoter abolish Gis1p-DNA interactions in vitro and abolish the regulation of DPP1 in vivo Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.75 diacylglycerol diphosphate + H2O Saccharomyces cerevisiae the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, and it also removes the phosphate from phosphatidate to form diacylglycerol, reaction of EC 3.1.3.4, genetic regulation, overview phosphatidate + phosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.75 Saccharomyces cerevisiae
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 gene DPP1, strains JOY37 and JOY38
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.75 diacylglycerol diphosphate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, and it also removes the phosphate from phosphatidate to form diacylglycerol, reaction of EC 3.1.3.4, genetic regulation, overview Saccharomyces cerevisiae phosphatidate + phosphate
-
 ?
3.6.1.75 diacylglycerol diphosphate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, and it also removes the phosphate from phosphatidate to form diacylglycerol, reaction of EC 3.1.3.4 Saccharomyces cerevisiae phosphatidate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.75 DGPP phosphatase
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 Saccharomyces cerevisiae
3.6.1.75 diacylglycerol pyrophosphate phosphatase
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 Saccharomyces cerevisiae
3.6.1.75 DPP1
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 Saccharomyces cerevisiae
3.6.1.75 DPP1-encoded DGPP phosphatase
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 Saccharomyces cerevisiae
3.6.1.75 More cf. EC 3.1.3.4 Saccharomyces cerevisiae