Literature summary extracted from

Ogawa, T.; Murakami, K.; Mori, H.; Ishii, N.; Tomita, M.; Yoshin, M.
Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli (2007), J. Bacteriol., 189, 1176-1178.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.42	phosphoenolpyruvate	allosteric inhibition. Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt	Escherichia coli
4.1.3.1	phosphoenolpyruvate	uncompetitive inhibitor	Escherichia coli

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1.1.42	0.029	-	isocitrate	-	Escherichia coli

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.42	Escherichia coli	-	-	-
4.1.3.1	Escherichia coli	-	-	-
4.1.3.1	Escherichia coli K-12 W3110	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.42	isocitrate + NADP+	-	Escherichia coli	2-oxoglutarate + CO2 + NADPH + H+	-	?
1.1.1.42	isocitrate + NADP+	-	Escherichia coli K-12 W3110	2-oxoglutarate + CO2 + NADPH + H+	-	?
4.1.3.1	isocitrate	-	Escherichia coli	succinate + glyoxylate	-	?
4.1.3.1	isocitrate	-	Escherichia coli K-12 W3110	succinate + glyoxylate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.42	NADP-isocitrate dehydrogenase	-	Escherichia coli
4.1.3.1	ICL	-	Escherichia coli

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.1.1.42	0.31	-	phosphoenolpyruvate	pH 7.1	Escherichia coli
4.1.3.1	0.893	-	phosphoenolpyruvate	in 100 mM potassium phosphate buffer (pH 7.1), 10 mM MgCl2, 12 mM cysteine	Escherichia coli

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Release 2023.1 (January 2023)