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Literature summary extracted from

  • Wilderman, P.R.; Peters, R.J.
    A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase (2007), J. Am. Chem. Soc., 129, 15736-15737.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.2.3.18 A723S product is switched from abietadienes to 75% isopimara-7,15-diene + 21% sandaracopimaradiene Abies grandis

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.18 Abies grandis Q38710
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Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.3.18 (+)-copalyl diphosphate = abieta-7,13-diene + diphosphate reactions leading from intermediate abieta-8(14)-en-13-yl cation to product are driven by the electrostatic effect of the ionized diphopshate group Abies grandis
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.18 (+)-copalyl-diphosphate reaction intermediate is abieta-8(14)-en-13-yl cation Abies grandis abieta-7,13-diene + abieta-8(14),13(15)-diene + abieta-8(14),12-diene + diphosphate
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