Literature summary extracted from

Jiang, J.; He, X.; Cane, D.E.
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin (2006), J. Am. Chem. Soc., 128, 8128-8129.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.2.3.22	for expression in Escherichia coli	Streptomyces coelicolor

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.2.3.22	Cu2+	suppresses the formation of geosmin by factor 3 or more	Streptomyces coelicolor
4.2.3.22	Fe2+	suppresses the formation of geosmin by factor 3 or more	Streptomyces coelicolor

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
4.2.3.22	Mg2+	-	Streptomyces coelicolor

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.3.22	Streptomyces coelicolor	Q9X839	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.3.22	(2E,6E)-farnesyl diphosphate + H2O	-	Streptomyces coelicolor	(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate	trans-1,10-dimethyl-trans-9-decalol	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.2.3.22	germacradienol/germacrene D synthase	-	Streptomyces coelicolor

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
4.2.3.22	30	-	activity assay	Streptomyces coelicolor

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Release 2023.1 (January 2023)