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Literature summary extracted from

  • Lee, H.S.; Lee, T.H.; Lee, J.H.; Chae, C.S.; Chung, S.C.; Shin, D.S.; Shin, J.; Oh, K.B.
    Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera (2007), J. Agric. Food Chem., 55, 6923-6928.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.1 expressed in Escherichia coli strain BLR (DE3) Pyricularia grisea

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.1 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane
-
 Pyricularia grisea
4.1.3.1 2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane
-
 Pyricularia grisea
4.1.3.1 2,3-dibromo-4,5-dihydroxybenzyl alcohol
-
 Pyricularia grisea
4.1.3.1 2,3-dibromo-4,5-dihydroxybenzyl methyl ether
-
 Pyricularia grisea
4.1.3.1 3,5-dibromo-4-hydroxyphenylethylamine
-
 Pyricularia grisea
4.1.3.1 3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol
-
 Pyricularia grisea
4.1.3.1 3-nitropropionate
-
 Pyricularia grisea
4.1.3.1 additional information not inhibited by bromopyruvate Pyricularia grisea

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.1 Pyricularia grisea
-
-
-
4.1.3.1 Pyricularia grisea Guy 11
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.1 Ni-NTA column chromatography Pyricularia grisea

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.1 isocitrate
-
 Pyricularia grisea succinate + glyoxylate
-
 ?
4.1.3.1 isocitrate
-
 Pyricularia grisea Guy 11 succinate + glyoxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.1 ICL key enzyme in the glyoxylate cycle Pyricularia grisea

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.3.1 0.002
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane
4.1.3.1 0.0021
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol
4.1.3.1 0.0028
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane
4.1.3.1 0.0924
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 3-nitropropionate
4.1.3.1 0.0926
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,3-dibromo-4,5-dihydroxybenzyl alcohol
4.1.3.1 0.116
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 3,5-dibromo-4-hydroxyphenylethylamine
4.1.3.1 0.1256
-
 in 20 mM sodium phosphate buffer (pH 7.0), with 3.75 mM MgCl2 and 4.1 mM phenylhydrazine, at 37°C Pyricularia grisea 2,3-dibromo-4,5-dihydroxybenzyl methyl ether