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Literature summary extracted from
- MT1-MMP: a key regulator of cell migration in tissue (2006), IUBMB Life, 58, 589-596.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.80 | additional information | not inhibited by TIMP-1 | Homo sapiens | |
| 3.4.24.80 | reversion-inducing cysteine rich protein | - |
Homo sapiens | |
| 3.4.24.80 | testican 1 | - |
Homo sapiens | |
| 3.4.24.80 | testican 3 | - |
Homo sapiens | |
| 3.4.24.80 | TIMP-2 | - |
Homo sapiens | |
| 3.4.24.80 | TIMP-3 | - |
Homo sapiens | |
| 3.4.24.80 | TIMP-4 | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.80 | membrane | MMP-1 localizes at membrane structures called lamellipodia and invadopodia | Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.80 | Zn2+ | dependent | Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.80 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.80 | epithelial cell | - |
Homo sapiens | - |
| 3.4.24.80 | fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.80 | aggrecan + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | CD44 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Fibrin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Laminin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | laminin-5 beta3 chain + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | proMMP-13 + H2O | activation | Homo sapiens | ? | - |
? | |
| 3.4.24.80 | proMMP-2 + H2O | activation | Homo sapiens | ? | - |
? | |
| 3.4.24.80 | proMMP-8 + H2O | activation | Homo sapiens | ? | - |
? | |
| 3.4.24.80 | syndecan-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | type II collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | type III collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.80 | membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
| 3.4.24.80 | MMP14 | - |
Homo sapiens |
| 3.4.24.80 | MT1-MMP | - |
Homo sapiens |
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