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Literature summary extracted from

  • Charlie, N.K.; Thomure, A.M.; Schade, M.A.; Miller, K.G.
    The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network (2006), Genetics, 173, 111-130.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.53 D448N mutation in conserved active site residue, loss of enzyme function does not affect steady-state acetylcholine release or reception Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.53 additional information Caenorhabditis elegans isoform PDE4 regulates both GalphaS-dependent and GalphaS-indeoendent cAMP pools in the neurons controling locomotion rate ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Caenorhabditis elegans
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 nervous system strong expression of isoform PDE4 throughout the nervous system Caenorhabditis elegans
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 additional information isoform PDE4 regulates both GalphaS-dependent and GalphaS-indeoendent cAMP pools in the neurons controling locomotion rate Caenorhabditis elegans ?
-
 ?