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Literature summary extracted from

  • Parra, M.; Mahmoudi, T.; Verdin, E.
    Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes (2007), Genes Dev., 21, 638-643.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.53 expression in DO11/10 T cells, downregulation of myosin phosphatase genes by using siRNA for PP1 isoforms and MYPT1 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.53 Mus musculus
-
 BALB/c
-
3.1.3.53 Mus musculus BALB/c
-
 BALB/c
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.53 by immunoprecipitation from primary thymocytes using anti-PP1a, anti-PP1b, anti-MYPT1 antibodies in combination with protein A-Sepharose slurry, myosin phosphatase subunits PP1b and MYPT1 coimmunoprecipitate with HDAC7 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.53 thymocyte T cell Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.53 histone deacetylase 7 phosphate + H2O HDAC7, dephosphorylation induces reimport into the nucleus Mus musculus histone deacetylase 7 + phosphate
-
 ?
3.1.3.53 histone deacetylase 7 phosphate + H2O HDAC7, dephosphorylation induces reimport into the nucleus Mus musculus BALB/c histone deacetylase 7 + phosphate
-
 ?
3.1.3.53 myosin light-chain phosphate + H2O
-
 Mus musculus myosin light-chain + phosphate
-
 ?
3.1.3.53 myosin light-chain phosphate + H2O
-
 Mus musculus BALB/c myosin light-chain + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.53 More myosin phosphatase is a heterotrimer composed of the catalytic subunit belonging to protein phosphatase 1 PP1, the myosin phosphatase targeting subunit MYPT1, and M21 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.3.53 myosin phosphatase
-
 Mus musculus
3.1.3.53 MYPT1
-
 Mus musculus
3.1.3.53 PP1
-
 Mus musculus