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Literature summary extracted from

  • Takeuchi, M.; Harigai, M.; Momohara, S.; Ball, E.; Abe, J.; Furuichi, K.; Kamatani, N.
    Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase (2007), Gene, 399, 174-180.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 expression of isozyme DPPL1 in Spodoptera frugiperda Sf9 cells Homo sapiens
3.1.3.4 expression of isozyme DPPL2 in Spodoptera frugiperda Sf9 cells Homo sapiens
3.6.1.75 expression of isozyme DPPL1 in Spodoptera frugiperda Sf9 cells Homo sapiens
3.6.1.75 expression of isozyme DPPL2 in Spodoptera frugiperda Sf9 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 NEM inhibition of isozyme DPPL1; inhibition of isozyme DPPL2 Homo sapiens
3.6.1.75 NEM inhibition of isozyme DPPL1; inhibition of isozyme DPPL2 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.4 0.041
-
 diacylglycerol diphosphate pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens
3.1.3.4 0.104
-
 diacylglycerol diphosphate pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens
3.1.3.4 0.277
-
 phosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens
3.1.3.4 0.295
-
 lysophosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens
3.1.3.4 0.506
-
 phosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens
3.1.3.4 0.58
-
 lysophosphatidic acid pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens
3.6.1.75 0.041
-
 diacylglycerol diphosphate pH 6.5, 37°C, recombinant isozyme DPPL2 Homo sapiens
3.6.1.75 0.104
-
 diacylglycerol diphosphate pH 6.5, 37°C, recombinant isozyme DPPL1 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 additional information isozyme DPPL1 is Mg2+-independent Homo sapiens
3.1.3.4 additional information isozyme DPPL2 is Mg2+-independent Homo sapiens
3.6.1.75 additional information isozyme DPPL1 is Mg2+-independent Homo sapiens
3.6.1.75 additional information isozyme DPPL2 is Mg2+-independent Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens Q5VZY2 DPPL2; isozyme DPPL2
-
3.1.3.4 Homo sapiens Q8NEB5 DPPL1; isozyme DPPL1
-
3.6.1.75 Homo sapiens Q5VZY2 DPPL2; isozyme DPPL2
-
3.6.1.75 Homo sapiens Q8NEB5 DPPL1; isozyme DPPL1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 A-549 cell
-
 Homo sapiens
-
3.1.3.4 blood vessel synovium containing, specific expression of DPPL2 Homo sapiens
-
3.1.3.4 brain isozyme DPPL2 Homo sapiens
-
3.1.3.4 endothelial cell isozyme DPPL2 Homo sapiens
-
3.1.3.4 endothelium specific expression of DPPL2, expression in endothelial cell lines, overview Homo sapiens
-
3.1.3.4 IM-9 cell
-
 Homo sapiens
-
3.1.3.4 JURKAT cell
-
 Homo sapiens
-
3.1.3.4 kidney isozyme DPPL2 Homo sapiens
-
3.1.3.4 MCF-7 cell
-
 Homo sapiens
-
3.1.3.4 additional information DPPL1 is ubiquitously expressed in various tissues and cells, overview Homo sapiens
-
3.1.3.4 additional information DPPL2 mRNA is restricted to several tissues, expression in cancer cell lines, overview Homo sapiens
-
3.1.3.4 PC-3 cell
-
 Homo sapiens
-
3.1.3.4 plasma cell specific expression of DPPL2 Homo sapiens
-
3.1.3.4 T-lymphocyte specific expression of DPPL2 Homo sapiens
-
3.1.3.4 testis isozyme DPPL2 Homo sapiens
-
3.1.3.4 THP-1 cell
-
 Homo sapiens
-
3.1.3.4 WiDr cell
-
 Homo sapiens
-
3.6.1.75 A-549 cell
-
 Homo sapiens
-
3.6.1.75 blood vessel synovium containing, specific expression of isozyme DPPL2 Homo sapiens
-
3.6.1.75 brain isozyme DPPL2 Homo sapiens
-
3.6.1.75 endothelial cell isozyme DPPL2 Homo sapiens
-
3.6.1.75 endothelium specific expression of DPPL2, expression in endothelial cell lines, overview Homo sapiens
-
3.6.1.75 IM-9 cell
-
 Homo sapiens
-
3.6.1.75 JURKAT cell
-
 Homo sapiens
-
3.6.1.75 kidney isozyme DPPL2 Homo sapiens
-
3.6.1.75 MCF-7 cell
-
 Homo sapiens
-
3.6.1.75 additional information DPPL1 is ubiquitously expressed in various tissues and cells, overview Homo sapiens
-
3.6.1.75 additional information DPPL2 mRNA is restricted to several tissues, expression in cancer cell lines, overview Homo sapiens
-
3.6.1.75 PC-3 cell
-
 Homo sapiens
-
3.6.1.75 plasma cell specific expression of isozyme DPPL2 Homo sapiens
-
3.6.1.75 T-lymphocyte specific expression of isozyme DPPL2 Homo sapiens
-
3.6.1.75 testis isozyme DPPL2 Homo sapiens
-
3.6.1.75 THP-1 cell
-
 Homo sapiens
-
3.6.1.75 WiDr cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL1 Homo sapiens ?
-
 ?
3.1.3.4 diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL2 Homo sapiens ?
-
 ?
3.1.3.4 lysophosphatidic acid + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.4 phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?
3.6.1.75 diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL1 Homo sapiens diacylglycerol phosphate + phosphate
-
 ?
3.6.1.75 diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL2 Homo sapiens diacylglycerol phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 DPPL1
-
 Homo sapiens
3.1.3.4 DPPL2
-
 Homo sapiens
3.1.3.4 More cf. EC 3.1.3.B2 Homo sapiens
3.1.3.4 PAP
-
 Homo sapiens
3.1.3.4 phosphatidate phosphatase
-
 Homo sapiens
3.6.1.75 DGPP phosphatase
-
 Homo sapiens
3.6.1.75 diacylglycerol pyrophosphate phosphatase
-
 Homo sapiens
3.6.1.75 DPPL1
-
 Homo sapiens
3.6.1.75 DPPL2
-
 Homo sapiens
3.6.1.75 More cf. EC 3.1.3.4 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.4 37
-
 assay at Homo sapiens
3.6.1.75 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 6.5
-
 assay at Homo sapiens
3.6.1.75 6.5
-
 assay at Homo sapiens