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Literature summary extracted from

  • Yanaka, N.; Nogusa, Y.; Fujioka, Y.; Yamashita, Y.; Kato, N.
    Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells (2007), FEBS Lett., 581, 712-718.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.44 expressed as GST-tag fusion protein in Escherichia coli BL21(DE3) Gold Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.46 additional information a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.44 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.1.4.44 Golgi apparatus
-
 Homo sapiens 5794
-
3.1.4.44 membrane
-
 Homo sapiens 16020
-
3.1.4.44 membrane integral membrane protein Mus musculus 16020
-
3.1.4.44 mitochondrion
-
 Homo sapiens 5739
-
3.1.4.44 plasma membrane
-
 Homo sapiens 5886
-
3.1.4.44 vacuole
-
 Homo sapiens 5773
-
3.1.4.46 growth cone
-
 Mus musculus 30426
-
3.1.4.46 perinuclear space
-
 Mus musculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.44 37700
-
 x * 37700, calculated from the deduced amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.44 glycerophosphoinositol + H2O Homo sapiens
-
 glycerol 3-phosphate + inositol
-
 ?
3.1.4.44 glycerophosphoinositol + H2O Mus musculus enzyme selectively hydrolyzes glycerophosphoinositol glycerol 3-phosphate + inositol
-
 ?
3.1.4.46 glycerophosphodiester + H2O Mus musculus
-
 glycerol 3-phosphate + alcohol
-
 ?
3.1.4.46 additional information Mus musculus important role in neurite growth, a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.44 Homo sapiens Q9NZC3
-
-
3.1.4.44 Mus musculus
-
-
-
3.1.4.46 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.44 additional information several potential phosphorylation sites detected, possible regulation by kinase phosphorylation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.44 brain DNA-template obtained from a brain cDNA library Homo sapiens
-
3.1.4.46 brain widely expressed in the adult mouse brain Mus musculus
-
3.1.4.46 cerebellum
-
 Mus musculus
-
3.1.4.46 cerebral cortex
-
 Mus musculus
-
3.1.4.46 hypothalamus
-
 Mus musculus
-
3.1.4.46 Neuro-2a cell expression of GDE2 is significantly upregulated during neuronal differentiation by retinoic acid treatment hippocampus Mus musculus
-
3.1.4.46 neuron primary neurons Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.44 glycerophosphoinositol + H2O
-
 Homo sapiens glycerol 3-phosphate + inositol
-
 ?
3.1.4.44 glycerophosphoinositol + H2O enzyme selectively hydrolyzes glycerophosphoinositol Mus musculus glycerol 3-phosphate + inositol
-
 ?
3.1.4.46 glycerophosphodiester + H2O
-
 Mus musculus glycerol 3-phosphate + alcohol
-
 ?
3.1.4.46 additional information important role in neurite growth, a loss of function mutant of Neuro2A fails to form neurites upon retinoic acid treatment Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.44 ? x * 37700, calculated from the deduced amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.4.44 GDE1
-
 Mus musculus
3.1.4.44 GDE1
-
 Homo sapiens
3.1.4.44 GDE1/MIR16
-
 Homo sapiens
3.1.4.44 glycerophosphoinositol phosphodiesterase
-
 Homo sapiens
3.1.4.44 membrane interacting protein of regulator of G protein signaling 16
-
 Homo sapiens
3.1.4.44 membrane interacting protein of RGS16
-
 Homo sapiens
3.1.4.44 MIR16
-
 Homo sapiens
3.1.4.46 GDE2
-
 Mus musculus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.1.4.44 Homo sapiens calculated from the deduced amino acid sequence
-
 6.51