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Literature summary extracted from

  • Green, B.D.; Flatt, P.R.; Bailey, C.J.
    Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes (2006), Expert. Opin. Emerg. Drugs, 11, 525-539.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.14.5 medicine inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.14.5 glucagon-like peptide-1 + H2O Homo sapiens dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect ?
-
 ?
3.4.14.5 glucose-dependent insulinotropic polypeptide + H2O Homo sapiens dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-
3.4.14.5 Mus musculus
-
-
-
3.4.14.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 adrenal gland
-
 Homo sapiens
-
3.4.14.5 biliary duct
-
 Homo sapiens
-
3.4.14.5 brain endothelium Homo sapiens
-
3.4.14.5 endothelium of spleen, lung, brain and vessels supplying the liver Homo sapiens
-
3.4.14.5 gastrointestinal tract
-
 Homo sapiens
-
3.4.14.5 kidney
-
 Homo sapiens
-
3.4.14.5 lung endothelium Homo sapiens
-
3.4.14.5 lymph node
-
 Homo sapiens
-
3.4.14.5 mammary gland
-
 Homo sapiens
-
3.4.14.5 pancreas
-
 Homo sapiens
-
3.4.14.5 placenta
-
 Homo sapiens
-
3.4.14.5 prostate
-
 Homo sapiens
-
3.4.14.5 salivary gland
-
 Homo sapiens
-
3.4.14.5 spleen endothelium Homo sapiens
-
3.4.14.5 sweat gland
-
 Homo sapiens
-
3.4.14.5 thymus
-
 Homo sapiens
-
3.4.14.5 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 alpha1-microglobulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 aprotinin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 beta-casomorphin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 corticotropin-like intermediate lobe peptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 enterostatin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.14.5 gastrin-releasing peptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 glucagon-like peptide-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 glucagon-like peptide-1 + H2O dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect Homo sapiens ?
-
 ?
3.4.14.5 glucagon-like peptide-2 + H2O
-
 Mus musculus ?
-
 ?
3.4.14.5 glucose-dependent insulinotropic polypeptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 glucose-dependent insulinotropic polypeptide + H2O dipeptidyl peptidase IV inactivates the hormone, thereby cancelling the prandial insulinotropic effect Homo sapiens ?
-
 ?
3.4.14.5 growth hormone-releasing hormone + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 procolipase + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 prolactin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 Substance P + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 trypsinogen propeptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 Tyr-melanostatin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 dipeptidylpeptidase IV
-
 Mus musculus
3.4.14.5 dipeptidylpeptidase IV
-
 Homo sapiens
3.4.14.5 dipeptidylpeptidase IV
-
 Rattus norvegicus
3.4.14.5 DPP IV
-
 Mus musculus
3.4.14.5 DPP IV
-
 Homo sapiens
3.4.14.5 DPP IV
-
 Rattus norvegicus