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Literature summary extracted from

  • Newman, D.; Abuladze, N.; Scholz, K.; Dekant, W.; Tsuprun, V.; Ryazantsev, S.; Bondar, G.; Sassani, P.; Kurtz, I.; Pushkin, A.
    Specificity of aminoacylase III-mediated deacetylation of mercapturic acids (2007), Drug Metab. Dispos., 35, 43-50.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.14 DTT activates murine AAIII Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.14 expression in HEK293T cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.14 PCMB inhibits murine AAIII Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.14 0.25
-
 N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.28
-
 N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.3
-
 N-acetyl-S-(4-chlorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.3
-
 N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.4
-
 N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.5
-
 N-acetyl-S-(4-bromobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.6
-
 N-acetyl-S-(3-fluorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.8
-
 N-acetyl-S-(4-methoxybenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 0.9
-
 N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 1
-
 N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.1
-
 N-acetyl-S-benzyl-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.2
-
 N-acetyl-L-tryptophan 37°C, pH 7.5 Mus musculus
3.5.1.14 1.2
-
 N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.3
-
 N-alpha-acetyl-L-lysine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.3
-
 N-acetyl-S-(2-fluorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.4
-
 N-acetyl-L-tyrosine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.45
-
 N-acetyl-S-(2-chlorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.6
-
 N-acetyl-L-phenylalanine 37°C, pH 7.5 Mus musculus
3.5.1.14 1.8
-
 N-acetyl-L-histidine 37°C, pH 7.5 Mus musculus
3.5.1.14 5.3
-
 N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
3.5.1.114 0.25
-
 N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.28
-
 N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.3
-
 N-acetyl-S-(4-chlorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.3
-
 N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.4
-
 N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.5
-
 N-acetyl-S-(4-bromobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.6
-
 N-acetyl-S-(3-fluorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.8
-
 N-acetyl-S-(4-methoxybenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 0.9
-
 N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 1
-
 N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 1.1
-
 N-acetyl-S-benzyl-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 1.2
-
 N-acetyl-L-tryptophan pH 7.5, 37°C Mus musculus
3.5.1.114 1.2
-
 N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 1.3
-
 N-acetyl-L-lysine pH 7.5, 37°C Mus musculus
3.5.1.114 1.3
-
 N-acetyl-S-(2-fluorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 1.4
-
 N-acetyl-L-tyrosine pH 7.5, 37°C Mus musculus
3.5.1.114 1.45
-
 N-acetyl-S-(2-chlorobenzyl)-L-cysteine pH 7.5, 37°C Mus musculus
3.5.1.114 1.6
-
 N-acetyl-L-phenylalanine pH 7.5, 37°C Mus musculus
3.5.1.114 1.8
-
 N-acetyl-L-histidine pH 7.5, 37°C Mus musculus
3.5.1.114 5.3
-
 N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine pH 7.5, 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.14 cytoplasm
-
 Mus musculus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.114 additional information enzyme does not require metal ions Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.14 140000
-
 expressed in HEK293T cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.14 Mus musculus Q99JW2
-
-
3.5.1.114 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.114
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.14 kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.14 N-acetyl-L-histidine + H2O
-
 Mus musculus acetate + L-histidine
-
 ?
3.5.1.14 N-acetyl-L-phenylalanine + H2O
-
 Mus musculus acetate + L-phenylalanine
-
 ?
3.5.1.14 N-acetyl-L-tryptophan + H2O
-
 Mus musculus acetate + L-tryptophan
-
 ?
3.5.1.14 N-acetyl-L-tyrosine + H2O
-
 Mus musculus acetate + L-tyrosine
-
 ?
3.5.1.14 N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2,2-trichlorovinyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2-dichlorovinyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-dichlorovinyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(2-chlorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chlorobenzyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(2-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-fluorobenzyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(3-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(3-fluorobenzyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(4-bromobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-bromobenzyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(4-chlorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-chlorobenzyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-(4-methoxybenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-methoxybenzyl)-L-cysteine
-
 ?
3.5.1.14 N-acetyl-S-benzyl-L-cysteine + H2O
-
 Mus musculus acetate + S-benzyl-L-cysteine
-
 ?
3.5.1.14 N-alpha-acetyl-L-lysine + H2O
-
 Mus musculus acetate + L-lysine
-
 ?
3.5.1.114 additional information no activity with N-acetyl-L-cysteine, N-acetyl-L-aspartic acid and Nepsilon-acetyl-L-lysine Mus musculus ?
-
 ?
3.5.1.114 N-acetyl-L-histidine + H2O
-
 Mus musculus acetate + L-histidine
-
 ?
3.5.1.114 N-acetyl-L-lysine + H2O
-
 Mus musculus acetate + L-lysine
-
 ?
3.5.1.114 N-acetyl-L-phenylalanine + H2O
-
 Mus musculus acetate + L-phenylalanine
-
 ?
3.5.1.114 N-acetyl-L-tryptophan + H2O
-
 Mus musculus acetate + L-tryptophan
-
 ?
3.5.1.114 N-acetyl-L-tyrosine + H2O
-
 Mus musculus acetate + L-tyrosine
-
 ?
3.5.1.114 N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2,2-trichlorovinyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2-dichlorovinyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(2,2-dichlorovinyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(2-chlorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chlorobenzyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(2-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-fluorobenzyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(3-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(3-fluorobenzyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(4-bromobenzyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(4-bromobenzyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(4-chlorobenzyl)-L-cysteine + H2O good substrate Mus musculus acetate + S-(4-chlorobenzyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-(4-methoxybenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-methoxybenzyl)-L-cysteine
-
 ?
3.5.1.114 N-acetyl-S-benzyl-L-cysteine + H2O
-
 Mus musculus acetate + S-benzyl-L-cysteine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.1.14 homotetramer PAGE Mus musculus
3.5.1.114 tetramer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.5.1.14 AAIII
-
 Mus musculus
3.5.1.114 AAIII
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.14 40
-
-
 Mus musculus
3.5.1.114 40
-
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.114 7.5 7.7 in 50 mM Na-phosphate buffer Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.1.14 7.5 7.7
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.5.1.114 physiological function the enzyme mediates deacetylation of the mercapturic acids derived from the metabolism of trichloroethylene in the proximal tubule cells, and this process is involved in their toxicity Mus musculus