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Literature summary extracted from

  • Guerra-Araiza, C.; Amorim, M.A.; Camacho-Arroyo, I.; Garcia-Segura, L.M.
    Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum (2007), Dev. Neurobiol., 67, 510-520.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.26 3alpha,5alpha-tetrahydroprogesterone decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus Rattus norvegicus
2.7.11.26 5alpha-dihydroprogesterone decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus Rattus norvegicus
2.7.11.26 progesterone decreases expression and phosphorylation of GSK-3 beta in the cerebellum but not in the hypothalamus, regulation of tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Rattus norvegicus
-
 Wistar albino female rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 cerebellum
-
 Rattus norvegicus
-
2.7.11.26 additional information hippothalamus Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + protein PHF-1
-
 Rattus norvegicus ADP + protein PHF-1 phosphate
-
 ?
2.7.11.26 ATP + protein tau
-
 Rattus norvegicus ADP + protein tau phosphate
-
 ?
2.7.11.26 ATP + protein tau-1
-
 Rattus norvegicus ADP + protein tau-1 phosphate
-
 ?
2.7.11.26 additional information does not phosphorylate tau at epitope Ser 262 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 glycogen synthase kinase 3beta
-
 Rattus norvegicus
2.7.11.26 GSK-3 beta
-
 Rattus norvegicus