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Literature summary extracted from

  • Van der Veken, P.; Haemers, A.; Augustyns, K.
    Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery (2007), Curr. Top. Med. Chem., 7, 621-635.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.2 (3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
-
 Homo sapiens
3.4.14.2 (3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine UAMC00039, potent and specific inhibitor Homo sapiens
3.4.14.2 1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine
-
 Homo sapiens
3.4.14.2 1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine
-
 Homo sapiens
3.4.14.2 N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide
-
 Homo sapiens
3.4.14.2 [(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.2 0.019
-
 Lys-Pro-p-nitroanilide
-
 Homo sapiens
3.4.14.2 0.041
-
 Ala-Pro-p-nitroanilide
-
 Homo sapiens
3.4.14.2 0.227
-
 Gly-Pro-p-nitroanilide
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.14.2 58000
-
 2 * 58000, SDS-PAGE Homo sapiens
3.4.14.2 116000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.2 Ala-Pro-p-nitroanilide + H2O
-
 Homo sapiens Ala-Pro + p-nitroaniline
-
 ?
3.4.14.2 Gly-Pro-p-nitroanilide + H2O
-
 Homo sapiens Gly-Pro + p-nitroaniline
-
 ?
3.4.14.2 Lys-Pro-p-nitroanilide + H2O
-
 Homo sapiens Lys-Pro + p-nitroaniline
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.14.2 homodimer 2 * 58000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.14.2 dipeptidyl peptidase II strongly prefers proline at P1 followed by norleucine Homo sapiens
3.4.14.2 DPP II
-
 Homo sapiens
3.4.14.2 DPP7
-
 Homo sapiens
3.4.14.2 QPP
-
 Homo sapiens
3.4.14.2 quiescent cell proline dipeptidase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.14.2 3
-
 Lys-Pro-p-nitroanilide
-
 Homo sapiens
3.4.14.2 67.3
-
 Gly-Pro-p-nitroanilide
-
 Homo sapiens
3.4.14.2 77.7
-
 Lys-Pro-p-nitroanilide
-
 Homo sapiens
3.4.14.2 89
-
 Ala-Pro-p-nitroanilide
-
 Homo sapiens
3.4.14.2 105.4
-
 Ala-Pro-p-nitroanilide
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.14.2 0.00000048
-
-
 Homo sapiens (3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
3.4.14.2 0.00000048
-
-
 Homo sapiens [(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid
3.4.14.2 0.00013
-
-
 Homo sapiens (3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
3.4.14.2 0.00104
-
-
 Homo sapiens 1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine
3.4.14.2 0.0031
-
-
 Homo sapiens 1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine
3.4.14.2 0.0038
-
-
 Homo sapiens N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide