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Literature summary extracted from

  • Arroyo, A.G.; Genis, L.; Gonzalo, P.; Matias-Roman, S.; Pollan, A.; Galvez, B.G.
    Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease (2007), Curr. Pharm. Des., 13, 1787-1802.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.80 medicine therapeutic target in angiogenesis-related disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.80 expressed in breast adenocarcinoma cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.80 N4-hydroxyamino-2-isobutyl-3-(thienylthiomethyl) succinyl]-L-phenylalamine-methylamide
-
 Homo sapiens
3.4.24.80 reversion-inducing-cysteine-rich protein
-
 Homo sapiens
3.4.24.80 TIMP-2
-
 Homo sapiens
3.4.24.80 TIMP-3
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.80 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.80 Zn2+ dependent Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.80 glycoprotein glycosylation and palmitoylation of Cys 564 in the cytosolic tail Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.80 aggrecan + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 alpha1-proteinase inhibitor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 alpha2-macroglobulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 alpha5 integrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 CD44 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 entactin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 fibrillin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 Fibrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 Fibrinogen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 Gelatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 gelsolin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 KiSS-1/metastin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 Laminin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 MCP-3/CCL7 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 pericentrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 pro-matrix metalloproteinase-13 + H2O activation Homo sapiens ?
-
 ?
3.4.24.80 pro-matrix metalloproteinase-8 + H2O activation Homo sapiens ?
-
 ?
3.4.24.80 pro-tissue necrosis factor alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 pro-transforming growth factor beta + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 progelatinase A + H2O activation, gelatinase A is matrix metalloproteinase-2 Homo sapiens gelatinase A + ?
-
 ?
3.4.24.80 SDF-1/CXCL12 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 syndecan + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 tissue transglutaminase + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 Type I collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 type II collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 type III collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 Vitronectin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 membrane type 1-matrix metalloproteinase
-
 Homo sapiens
3.4.24.80 MT1-MMP
-
 Homo sapiens