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Literature summary extracted from

  • Can Demirdoegen, B.; Tuerkanoglu, A.; Bek, S.; Sanisoglu, Y.; Demirkaya, S.; Vural, O.; Arinc, E.; Adali, O.
    Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke (2008), Clin. Biochem., 41, 1-9.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.2 Q192R a naturally occuring polymorphism, 192QQ, 192RR or 192QR, that reduces PON1 activity and increases the risk of ischemic stroke, genotyping and phenotyping, allele frequency, the paraoxonase/arylesterase activity ratio is unaltered Homo sapiens
3.1.1.2 R192Q a naturally occuring polymorphism, 192QQ, 192RR or 192QR, that reduces PON1 activity and increases the risk of ischemic stroke, genotyping and phenotyping, allele frequency, the paraoxonase/arylesterase activity ratio is unaltered Homo sapiens
3.1.8.1 Q192R a naturally occuring polymorphism, 192QQ, 192RR or 192QR, that reduces PON1 activity and increases the risk of ischemic stroke, genotyping and phenotyping, allele frequency, the paraoxonase/arylesterase activity ratio is unaltered Homo sapiens
3.1.8.1 R192Q a naturally occuring polymorphism, 192QQ, 192RR or 192QR, that reduces PON1 activity and increases the risk of ischemic stroke, genotyping and phenotyping, allele frequency, the paraoxonase/arylesterase activity ratio is unaltered Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.2 additional information Homo sapiens the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview ?
-
 ?
3.1.8.1 additional information Homo sapiens the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens P27169
-
-
3.1.8.1 Homo sapiens P27169
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview Homo sapiens ?
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.8.1 additional information the enzyme is located on high-density lipoprotein and prevents low-density-lipoprotein and high-density-lipoprotein oxidation both in vivo and in vitro through hydrolysis of lipid peroxides, the risk of ischemic stroke is related to the genotype of PON1 192RQ polymorphisms, overview Homo sapiens ?
-
 ?
3.1.8.1 paraoxon + H2O
-
 Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.2 paraoxonase/arylesterase
-
 Homo sapiens
3.1.8.1 paraoxonase 1
-
 Homo sapiens
3.1.8.1 PON1
-
 Homo sapiens