Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gadepalli, R.S.; Rimoldi, J.M.; Fronczek, F.R.; Nillos, M.; Gan, J.; Deng, X.; Rodriguez-Fuentes, G.; Schlenk, D.
    Synthesis of fenthion sulfoxide and fenoxon sulfoxide enantiomers: effect of sulfur chirality on acetylcholinesterase activity (2007), Chem. Res. Toxicol., 20, 257-262.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 (R)-(+)-fenoxon sulfoxide
-
 Electrophorus electricus
3.1.1.7 (R)-(+)-fenoxon sulfoxide
-
 Homo sapiens
3.1.1.7 (R)-(+)-fenthion sulfoxide
-
 Electrophorus electricus
3.1.1.7 (R)-(+)-fenthion sulfoxide
-
 Homo sapiens
3.1.1.7 (rac) fenoxon sulfoxide
-
 Electrophorus electricus
3.1.1.7 (rac) fenoxon sulfoxide
-
 Homo sapiens
3.1.1.7 (rac) fenthion sulfoxide
-
 Electrophorus electricus
3.1.1.7 (rac) fenthion sulfoxide
-
 Homo sapiens
3.1.1.7 (S)-(-)-fenoxon sulfoxide
-
 Electrophorus electricus
3.1.1.7 (S)-(-)-fenoxon sulfoxide
-
 Homo sapiens
3.1.1.7 (S)-(-)-fenthion sulfoxide
-
 Electrophorus electricus
3.1.1.7 (S)-(-)-fenthion sulfoxide
-
 Homo sapiens
3.1.1.7 fenoxon
-
 Electrophorus electricus
3.1.1.7 fenoxon
-
 Homo sapiens
3.1.1.7 fenthion
-
 Electrophorus electricus
3.1.1.7 fenthion
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Electrophorus electricus
-
-
-
3.1.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 commercial preparation lyophilized recombinant enzyme Homo sapiens
-
3.1.1.7 commercial preparation lyophilized recombinant enzyme Electrophorus electricus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Electrophorus electricus thiocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens
3.1.1.7 AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 25
-
 assay at Homo sapiens
3.1.1.7 25
-
 assay at Electrophorus electricus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.5
-
 assay at Homo sapiens
3.1.1.7 7.5
-
 assay at Electrophorus electricus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 0.0012
-
 (R)-(+)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Homo sapiens
3.1.1.7 0.0013
-
 (R)-(+)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
3.1.1.7 0.0017
-
 fenoxon pH 7.5, 25°C, recombinant enzyme Homo sapiens
3.1.1.7 0.0017
-
 (rac) fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
3.1.1.7 0.0041
-
 fenoxon pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
3.1.1.7 0.0043
-
 (rac) fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Homo sapiens
3.1.1.7 0.0143
-
 fenthion pH 7.5, 25°C, recombinant enzyme Homo sapiens
3.1.1.7 0.0215
-
 (S)-(-)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
3.1.1.7 0.0221
-
 fenthion pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
3.1.1.7 0.0407
-
 (S)-(-)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.0065
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (R)-(+)-fenoxon sulfoxide
3.1.1.7 0.0069
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens (R)-(+)-fenoxon sulfoxide
3.1.1.7 0.0087
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (rac) fenoxon sulfoxide
3.1.1.7 0.0097
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens fenoxon
3.1.1.7 0.021
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus fenoxon
3.1.1.7 0.023
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens (rac) fenoxon sulfoxide
3.1.1.7 0.0807
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens fenthion
3.1.1.7 0.111
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (S)-(-)-fenoxon sulfoxide
3.1.1.7 0.114
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus fenthion
3.1.1.7 0.23
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens (S)-(-)-fenoxon sulfoxide
3.1.1.7 1
-
 above, pH 7.5, 25°C, recombinant enzyme Homo sapiens (rac) fenthion sulfoxide
3.1.1.7 1
-
 above, pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (rac) fenthion sulfoxide
3.1.1.7 1
-
 above, pH 7.5, 25°C, recombinant enzyme Homo sapiens (R)-(+)-fenthion sulfoxide
3.1.1.7 1
-
 above, pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (R)-(+)-fenthion sulfoxide
3.1.1.7 1
-
 above, pH 7.5, 25°C, recombinant enzyme Homo sapiens (S)-(+)-fenthion sulfoxide
3.1.1.7 1
-
 above, pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (S)-(+)-fenthion sulfoxide