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Literature summary extracted from

  • Guo, F.; Cavener, D.R.
    The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid (2007), Cell Metab., 5, 103-114.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 additional information the enzyme is activated by uncharged tRNA-dependent mechanisms Mus musculus

Application

EC Number Application Comment Organism
2.7.11.20 additional information novel function of GCN2, regulates lipid metabolism during leucine deprivation in addition to regulating amino acid metabolism Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.20 additional information GCN2-deficient mice fed a leucine-deprived diet, develop liver steatosis, genes related to triglyceride synthesis and expression of SREBP-1c and PPARg are not repressed. Beta-oxidation genes and fatty-acid transport genes are upregulated, mutant exhibits reduced lipid mobilization Mus musculus
2.7.11.20 additional information construction of Gcn2 knockout mice and effects on enzyme activity and leucine metabolism, phenotype, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] Mus musculus the reaction leads to derepression of transcription factor GCN4 ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] Mus musculus C57/BL6J the reaction leads to derepression of transcription factor GCN4 ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 additional information Mus musculus the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview ?
-
 ?
2.7.11.20 additional information Mus musculus C57/BL6J the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Mus musculus
-
-
-
2.7.11.20 Mus musculus
-
 C57BL/6J mice
-
2.7.11.20 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 liver
-
 Mus musculus
-
2.7.11.20 liver expression of lipogenic genes and the activity of fatty acid synthase in the liver are repressed and lipid stores in adipose tissue are mobilized in GCN2 wild-type mice upon leucine deprivation Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [eukaryotic translation elongation factor 2]
-
 Mus musculus ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] the reaction leads to derepression of transcription factor GCN4 Mus musculus ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [eukaryotic translation elongation factor 2]
-
 Mus musculus C57/BL6J ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [eukaryotic translation elongation factor 2] the reaction leads to derepression of transcription factor GCN4 Mus musculus C57/BL6J ADP + [eukaryotic translation elongation factor 2] phosphate
-
 ?
2.7.11.20 additional information the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview Mus musculus ?
-
 ?
2.7.11.20 additional information the GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of the essential amino acid leucine, thus, the enzyme acts as sensor for amino acid deficiency, overview Mus musculus C57/BL6J ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 GCN2
-
 Mus musculus
2.7.11.20 GCN2 eIF2alpha kinase
-
 Mus musculus
2.7.11.20 GCN2 kinase
-
 Mus musculus
2.7.11.20 general control nonderepressible 2 kinase
-
 Mus musculus