Literature summary extracted from

Zhao, T.; Zhang, H.; Guo, Y.; Zhang, Q.; Hua, G.; Lu, H.; Hou, Q.; Liu, H.; Fan, Z.
Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells (2007), Cell Death Differ., 14, 489-499.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.21.B4	expressed in Escherichia coli	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.21.B4	S214A	inactive	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.B4	Aprotinin	0.015 mM	Homo sapiens
3.4.21.B4	Phenylmethylsulfonylfluoride	2 mM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B4	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.21.B4	nickel chelation column chromatography	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.B4	benzyloxycarbonyl-Lys-thiobenzyl ester + H2O	-	Homo sapiens	benzyloxycarbonyl-Lys + thiobenzyl alcohol	-	?
3.4.21.B4	nucleosome assembly protein SET + H2O	-	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B4	GzmK	shows tryptase activity	Homo sapiens

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Release 2023.1 (January 2023)