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Literature summary extracted from
- Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo (2007), Cancer Res., 67, 2141-2149.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.2.99.18 | medicine | selective targeting of APE1/Ref-1 could enhance conventional cancer treatment such as radiotherapy | Mus musculus |
| 4.2.99.18 | medicine | selective targeting of APE1/Ref-1 could enhance conventional cancer treatment such as radiotherapy | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.99.18 | isoflavones | soy isoflavones decrease apurinic/apyrimidinic endonuclease 1/redox factor-1 expression | Homo sapiens |  |
| 4.2.99.18 | isoflavones | soy isoflavones decrease apurinic/apyrimidinic endonuclease 1/redox factor-1 expression | Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.2.99.18 | cytoplasm | - |
Mus musculus | 5737 | - |
| 4.2.99.18 | cytoplasm | - |
Homo sapiens | 5737 | - |
| 4.2.99.18 | nucleus | - |
Mus musculus | 5634 | - |
| 4.2.99.18 | nucleus | - |
Homo sapiens | 5634 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.99.18 | Homo sapiens | - |
- |
- |
| 4.2.99.18 | Mus musculus | - |
male nude mice, BALB/c nu/nu 5-6 weeks old | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.2.99.18 | PC-3 cell | human prostate cancer cell line | Homo sapiens | - |
| 4.2.99.18 | prostate cancer cell | - |
Mus musculus | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.99.18 | APE1 | - |
Mus musculus |
| 4.2.99.18 | APE1 | - |
Homo sapiens |
| 4.2.99.18 | apurinic/apyrimidinic endonuclease 1 | - |
Mus musculus |
| 4.2.99.18 | apurinic/apyrimidinic endonuclease 1 | - |
Homo sapiens |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | - |
Mus musculus |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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