Any feedback?
Literature summary extracted from
- The role of Granzyme B in atheromatous diseases (2007), Can. J. Physiol. Pharmacol., 85, 89-95.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.79 | cathepsin C | proteolytically activates in cytotoxic granules | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.79 | medicine | granzyme B may play a key role in ateromatous diseases. Role in cardiac allograft vasculopathy and atherosclerosis | Mus musculus |
| 3.4.21.79 | medicine | granzyme B may play a key role in ateromatous diseases. Role in cardiac allograft vasculopathy and atherosclerosis | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.79 | additional information | granzyme B-deficient mice possess a normal phenotype, with the exception of reduced CTL-mediated target cell apoptosis, antiviral responses, and tumor cell clearance. Treg cells from granzyme B-deficient mice can not suppress immune responses as effectively as Treg cells from wild-type mice. Granzyme B-deficient recipient mice exhibit reduced allograft vasculopathy and increased susceptibility to allgergen-induced asthma. Hearts from 129J donor mice transplanted into granzyme B-KO mice exhibit significantly smaller lesions and luminal narrowing compared with wild-type recipients | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.79 | (S)-3-((2S,5S)-5-((2S,3S)-2-acetamido-3-methylpentanamido)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxamido)-4-oxobutanoic acid | - |
Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.79 | Homo sapiens | - |
- |
- |
| 3.4.21.79 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.79 | blood | basophil | Homo sapiens | - |
| 3.4.21.79 | keratinocyte | - |
Homo sapiens | - |
| 3.4.21.79 | leukocyte | - |
Homo sapiens | - |
| 3.4.21.79 | macrophage | - |
Homo sapiens | - |
| 3.4.21.79 | additional information | increased protein levels in all regions of vessels with advanced atherosclerosis, i.e., superficial intima, deep intima, and the media. In the intima granzyme B is present within lipid-rich regions in which it localizes to TUNEL-positive foam cells of atherosclerotic plaques. In allograft vasculopathy increase of protein levels only in the deep intima | Homo sapiens | - |
| 3.4.21.79 | additional information | Treg cell | Mus musculus | - |
| 3.4.21.79 | placenta | perforin-independent expression | Homo sapiens | - |
| 3.4.21.79 | smooth muscle cell | perforin-independent expression | Homo sapiens | - |
| 3.4.21.79 | testis | perforin-independent expression | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.79 | aggrecan proteoglycan + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.79 | autoantigen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.79 | BID + H2O | - |
Homo sapiens | truncated BID + ? | - |
? | |
| 3.4.21.79 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.79 | lamin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.79 | Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.79 | cytotoxic T-lymphocyte-associated gene transcript-1 | - |
Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
