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Literature summary extracted from

  • McKinnon, T.A.; Chion, A.C.; Millington, A.J.; Lane, D.A.; Laffan, M.A.
    N-linked glycosylation of VWF modulates its interaction with ADAMTS13 (2008), Blood, 111, 3042-3049.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 expressed in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 von Willebrand factor + H2O Homo sapiens ADAMTS13 cleaves the bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.87
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 Collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.87 additional information PNGase-treated von Willebrand factor is more succeptible to proteolysis by ADAMTS13 and binds with increased affinity Homo sapiens ?
-
 ?
3.4.24.87 von Willebrand factor + H2O ADAMTS13 cleaves the bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS13
-
 Homo sapiens
3.4.24.87 von Willebrand factor cleaving protease
-
 Homo sapiens
3.4.24.87 VWF cleaving protease
-
 Homo sapiens