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Literature summary extracted from

  • Qiu, Y.; Gao, J.; Guo, F.; Qiao, Y.; Li, D.
    Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase (2007), Bioorg. Med. Chem. Lett., 17, 6164-6168.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.33
-
 Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.33 D306A low activity Rattus norvegicus
4.1.1.33 D306E low activity Rattus norvegicus
4.1.1.33 D306N low activity Rattus norvegicus
4.1.1.33 K208A low activity Rattus norvegicus
4.1.1.33 K23A no activity Rattus norvegicus
4.1.1.33 K27A low activity Rattus norvegicus
4.1.1.33 R154A low activity Rattus norvegicus
4.1.1.33 R162A low activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.33 1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol
-
 Rattus norvegicus
4.1.1.33 1-(diphosphenyloxy)-3-methylpentan-3-ol
-
 Rattus norvegicus
4.1.1.33 1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol
-
 Rattus norvegicus
4.1.1.33 2,2-difluoromevalonate 5-diphosphate
-
 Rattus norvegicus
4.1.1.33 2-fluoromevalonate 5-diphosphate irreversible inhibitor Rattus norvegicus
4.1.1.33 3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate
-
 Rattus norvegicus
4.1.1.33 4-(diphosphenyloxy)-2-methylbutan-2-ol
-
 Rattus norvegicus
4.1.1.33 4-(diphosphenyloxy)-2-phenylbutan-2-ol
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.33 0.036
-
 5-diphosphomevalonate wild type enzyme Rattus norvegicus
4.1.1.33 0.53
-
 ATP wild type enzyme Rattus norvegicus
4.1.1.33 0.75
-
 5-diphosphomevalonate mutant enzyme K27A Rattus norvegicus
4.1.1.33 0.92
-
 5-diphosphomevalonate mutant enzyme R154A Rattus norvegicus
4.1.1.33 1.4
-
 ATP mutant enzyme R154A Rattus norvegicus
4.1.1.33 1.87
-
 ATP mutant enzyme K27A Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.33 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.33 nickel metal affinity column chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.33 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.33 ATP + 5-diphosphomevalonate
-
 Rattus norvegicus ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.33 MDD
-
 Rattus norvegicus
4.1.1.33 mevalonate 5'-diphosphate decarboxylase
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.1.33 0.0075
-
-
 Rattus norvegicus 2,2-difluoromevalonate 5-diphosphate
4.1.1.33 0.02
-
-
 Rattus norvegicus 3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate
4.1.1.33 0.05
-
-
 Rattus norvegicus 1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol
4.1.1.33 0.06
-
-
 Rattus norvegicus 4-(diphosphenyloxy)-2-methylbutan-2-ol
4.1.1.33 0.08
-
-
 Rattus norvegicus 1-(diphosphenyloxy)-3-methylpentan-3-ol
4.1.1.33 0.12
-
-
 Rattus norvegicus 1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol
4.1.1.33 0.14
-
-
 Rattus norvegicus 4-(diphosphenyloxy)-2-phenylbutan-2-ol