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Literature summary extracted from

  • Agusti, R.; Giorgi, M.E.; Mendoza, V.M.; Gallo-Rodriguez, C.; de Lederkremer, R.M.
    Comparative rates of sialylation by recombinant trans-sialidase and inhibitor properties of synthetic oligosaccharides from Trypanosoma cruzi mucins-containing galactofuranose and galactopyranose (2007), Bioorg. Med. Chem., 15, 2611-2616.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 Galp(beta1,2)Galf(beta1,4)GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)Galf(beta1,4)GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)[Galp(beta1,3)]Gal
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)[Galp(beta1,3)]GalOBn
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)[Galp(beta1,3)]Galol
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,6)GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,6)GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,6)GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.18 0.05
-
 Galp(beta1,6)GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 0.08
-
 Galp(beta1,6)GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 0.08
-
 Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 0.08
-
 Galp(beta1,2)[Galp(beta1,3)]Gal
-
 Trypanosoma cruzi
3.2.1.18 0.09
-
 Galp(beta1,2)Galf(beta1,4)GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 0.1
-
 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 0.15
-
 Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 0.17
-
 Galp(beta1,6)GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 0.17
-
 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 0.17
-
 Galp(beta1,2)[Galp(beta1,3)]GalOBn
-
 Trypanosoma cruzi
3.2.1.18 0.18
-
 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 0.25
-
 Galp(beta1,2)[Galp(beta1,3)]Galol
-
 Trypanosoma cruzi
3.2.1.18 0.27
-
 Galp(beta1,2)Galf(beta1,4)GlcNAc
-
 Trypanosoma cruzi
3.2.1.18 0.31
-
 Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 0.82
-
 Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi
3.2.1.18 1.07
-
 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi
3.2.1.18 2.35
-
 Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)Galf(beta1,4)GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Gal
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]GalOBn
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galol
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi lactose + Neu5Ac(alpha2,3)[Galp(beta1,2)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,6)GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,6)GlcNAcOBn
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,6)GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNA
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNAc
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
-
 Trypanosoma cruzi ?
-
 ?
3.2.1.18 3'-sialyllactose + mucin oligosaccharide
-
 Trypanosoma cruzi ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 TcTS
-
 Trypanosoma cruzi
3.2.1.18 trans-sialidase
-
 Trypanosoma cruzi

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.18 0.61
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
3.2.1.18 0.7
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
3.2.1.18 0.76
-
-
 Trypanosoma cruzi Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
3.2.1.18 0.85
-
-
 Trypanosoma cruzi Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
3.2.1.18 0.85
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
3.2.1.18 0.86
-
-
 Trypanosoma cruzi Galp(beta1,6)[Galf(beta1,4)]GlcNAc
3.2.1.18 0.86
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Gal
3.2.1.18 0.93
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]Galol
3.2.1.18 0.94
-
-
 Trypanosoma cruzi Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
3.2.1.18 0.98
-
-
 Trypanosoma cruzi Galp(beta1,6)GlcNAcol
3.2.1.18 1.11
-
-
 Trypanosoma cruzi Galp(beta1,6)GlcNAcOBn
3.2.1.18 1.13
-
-
 Trypanosoma cruzi Galp(beta1,2)[Galp(beta1,3)]GalOBn
3.2.1.18 1.14
-
-
 Trypanosoma cruzi Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
3.2.1.18 1.26
-
-
 Trypanosoma cruzi Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
3.2.1.18 1.33
-
-
 Trypanosoma cruzi Galp(beta1,6)[Galf(beta1,4)]GlcNAc
3.2.1.18 1.67
-
-
 Trypanosoma cruzi Galp(beta1,2)Galf(beta1,4)GlcNAcol
3.2.1.18 2.22
-
-
 Trypanosoma cruzi Galp(beta1,6)GlcNAc
3.2.1.18 4.43
-
-
 Trypanosoma cruzi Galp(beta1,2)Galf(beta1,4)GlcNAc