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Literature summary extracted from

  • Fisher, S.Z.; Tariku, I.; Case, N.M.; Tu, C.; Seron, T.; Silverman, D.N.; Linser, P.J.; McKenna, R.
    Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1) (2006), Biochim. Biophys. Acta, 764, 1413-1419.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.1 medicine there are amino acid differences in the active site of AaCA1 of Aedes aegypti and human carbonic anhydrases. Terefore this enzyme could be a potential drug target of selective carbonic anhydrase inhibitors for the control of mosquito populations and the pathogens they carry Aedes aegypti

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.1 expression in Escherichia coli BL21 Aedes aegypti

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 ethoxzolamide
-
 Aedes aegypti
4.2.1.1 methazolamide
-
 Aedes aegypti

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Aedes aegypti
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.1
-
 Aedes aegypti

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 larva midgut Aedes aegypti
-
4.2.1.1 midgut of larva Aedes aegypti
-

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 AaCA1
-
 Aedes aegypti
4.2.1.1 alpha-CA
-
 Aedes aegypti

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.0000019
-
 ethoxzolamide
-
 Aedes aegypti
4.2.1.1 0.0000027
-
 methazolamide
-
 Aedes aegypti