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Literature summary extracted from
- Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position (2006), Biochim. Biophys. Acta, 1758, 499-508.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | 1-palmitoyl-2-arachidonoylphosphatidylcholine | stimulates arylesterase activity | Homo sapiens |  |
| 3.1.1.2 | 1-palmitoyl-2-linoleoylphosphatidylcholine | stimulates arylesterase activity | Homo sapiens | |
| 3.1.1.2 | didecanoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.1.2 | dilauroylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.1.2 | dilinoleoylphosphatidylcholine | stimulates arylesterase activity | Homo sapiens | |
| 3.1.1.2 | dimyristoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.1.2 | dimyristoylphosphatidylglycerol | activates the arylesterase activity and inhibits paraoxonase activity | Homo sapiens | |
| 3.1.1.2 | dipalmitoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.1.2 | phosphatidylinositol | enhances arylesterase activity, but slightly decreases paraoxonase activity | Homo sapiens | |
| 3.1.8.1 | didecanoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.8.1 | dilauroylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.8.1 | dimyristoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
| 3.1.8.1 | dipalmitoylphosphatidylcholine | stimulation of arylesterase activity is greater than stimulation of paraoxonase activity | Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | dimyristoylphosphatidic acid | 0.4 mM, 81% inhibition of arylesterase activity, 64% inhibition of paraoxonase activity | Homo sapiens | |
| 3.1.1.2 | dimyristoylphosphatidylserine | no significant inhibition of both paraoxonase and arylesterase activity up to 0.030 mM, remarkable inhibition of both activities at 0.10.4 mM, with a greater inhibition of arylesterase activity | Homo sapiens | |
| 3.1.1.2 | additional information | 0.2 mM dimyristoylphosphatidylethanol inhibits paraoxonase activity but has no effect on arylesterase activity | Homo sapiens | |
| 3.1.8.1 | dimyristoylphosphatidic acid | 0.4 mM, 81% inhibition of arylesterase activity, 64% inhibition of paraoxonase activity | Homo sapiens | |
| 3.1.8.1 | dimyristoylphosphatidylethanol | 0.2 mM, 20% inhibition of paraoxonase activity, no effect on arylesterase activity | Homo sapiens | |
| 3.1.8.1 | dimyristoylphosphatidylglycerol | activates the arylesterase activity and inhibits paraoxonase activity | Homo sapiens | |
| 3.1.8.1 | dimyristoylphosphatidylserine | no significant inhibition of both activities up to 0.030 mM, remarkable inhibition of both activities at 0.10.4 mM, with a greater inhibition of arylesterase activity | Homo sapiens | |
| 3.1.8.1 | phosphatidylinositol | enhances arylesterase activity, but slightly decreases paraoxonase activity | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | P27169 | - |
- |
| 3.1.8.1 | Homo sapiens | P27169 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.2 | - |
Homo sapiens |
| 3.1.8.1 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | blood plasma | - |
Homo sapiens | - |
| 3.1.8.1 | blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
| 3.1.8.1 | paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 7.4 | - |
assay at | Homo sapiens |
| 3.1.8.1 | 7.4 | - |
assay at | Homo sapiens |
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