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Literature summary extracted from

  • Vila, A.; Rosengarth, A.; Piomelli, D.; Cravatt, B.; Marnett, L.J.
    Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase (2007), Biochemistry, 46, 9578-9585.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 URB-602 a specific MGL inhibitor Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.23 0.01
-
 2-arachidonoylglycerol pH 8.0, 37°C Rattus norvegicus
3.1.1.23 0.133
-
 prostaglandin D2-G pH 8.0, 37°C Rattus norvegicus
3.1.1.23 0.15
-
 prostaglandin E2-G pH 8.0, 37°C Rattus norvegicus
3.1.1.23 0.311
-
 prostaglandin F3alpha-G pH 8.0, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.23 additional information Rattus norvegicus the enzyme is involved in prostaglandin metabolism in brain particulate fractions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.23 additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
-
 Rattus norvegicus arachidonic acid + glycerol
-
 ?
3.1.1.23 additional information substrate specificity, overview Rattus norvegicus ?
-
 ?
3.1.1.23 additional information the enzyme is involved in prostaglandin metabolism in brain particulate fractions Rattus norvegicus ?
-
 ?
3.1.1.23 prostaglandin D2-G + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.23 prostaglandin E2-G + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.1.23 prostaglandin F3alpha-G + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MGL
-
 Rattus norvegicus
3.1.1.23 monoacylglycerol lipase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.23 37
-
 assay at Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.1.23 0.07
-
 prostaglandin D2-G pH 8.0, 37°C Rattus norvegicus
3.1.1.23 0.14
-
 prostaglandin F3alpha-G pH 8.0, 37°C Rattus norvegicus
3.1.1.23 0.16
-
 prostaglandin E2-G pH 8.0, 37°C Rattus norvegicus
3.1.1.23 0.35
-
 2-arachidonoylglycerol pH 8.0, 37°C Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.23 8
-
 assay at Rattus norvegicus