Literature summary extracted from
Bandele, O.J.; Osheroff, N.
Bioflavonoids as poisons of human topoisomerase II alpha and II beta (2007), Biochemistry, 46, 6097-6108.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
5.6.2.2 |
apigenin |
0.05 mM, 5fold increase in DNA-cleavage activity for isoform II beta, 2fold increase for isoform II alpha |
Homo sapiens |
|
5.6.2.2 |
etoposide |
0.05 mM, 10fold increase in DNA-cleavage activity for isoform II beta, 6fold increase for isoform II alpha |
Homo sapiens |
|
5.6.2.2 |
genistein |
0.05 mM, 8fold increase in DNA-cleavage activity for isoform II beta, 5fold increase for isoform II alpha |
Homo sapiens |
|
5.6.2.2 |
luteolin |
0.05 mM, 7fold increase in DNA-cleavage activity for isoform II beta, 3fold increase for isoform II alpha |
Homo sapiens |
|
5.6.2.2 |
additional information |
effect of flavones, flavonols, and isoflavones on DNA cleavage activity requires a 5-OH and a 4-OH group and is enhanced by the presence of additional hydroxyl groups on the pendant ring |
Homo sapiens |
|
5.6.2.2 |
myricetin |
0.05 mM, 7fold increase in DNA-cleavage activity for isoform II beta, 4fold increase for isoform II alpha |
Homo sapiens |
|
5.6.2.2 |
quercetin |
0.05 mM, 7fold increase in DNA-cleavage activity for isoform II beta, 4fold increase for isoform II alpha |
Homo sapiens |
|
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
5.6.2.2 |
apigenin |
inhibition of enzyme-mediated religation of DNA |
Homo sapiens |
|
5.6.2.2 |
etoposide |
inhibition of enzyme-mediated religation of DNA |
Homo sapiens |
|
5.6.2.2 |
genistein |
inhibition of enzyme-mediated religation of DNA |
Homo sapiens |
|
5.6.2.2 |
luteolin |
inhibition of enzyme-mediated religation of DNA |
Homo sapiens |
|
5.6.2.2 |
myricetin |
inhibition of enzyme-mediated religation of DNA |
Homo sapiens |
|
5.6.2.2 |
quercetin |
inhibition of enzyme-mediated religation of DNA |
Homo sapiens |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
5.6.2.2 |
Homo sapiens |
- |
isoforms II alpha and II beta |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
5.6.2.2 |
CEM cell |
leukemia cell |
Homo sapiens |
- |