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Literature summary extracted from

  • Perez, L.; Kerrigan, J.E.; Li, X.; Fan, H.
    Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity (2007), Biochem. Cell Biol., 85, 141-149.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 expressed in the M1 cell line Mesocricetus auratus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.86 M435I mutation inactivates ectodomain shedding activity Mesocricetus auratus
3.4.24.86 M435L mutation inactivates ectodomain shedding activity Mesocricetus auratus
3.4.24.86 M435S mutation inactivates ectodomain shedding activity Mesocricetus auratus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.86 Zn2+ contains a catalytic zinc complex Mesocricetus auratus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Mesocricetus auratus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.86 Sepharose column chromatography Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 L-selectin + H2O
-
 Mesocricetus auratus ?
-
 ?
3.4.24.86 p75 tumour necrosis factor receptor + H2O
-
 Mesocricetus auratus ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mesocricetus auratus soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Mesocricetus auratus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM17
-
 Mesocricetus auratus
3.4.24.86 TACE
-
 Mesocricetus auratus
3.4.24.86 TNF-alpha converting enzyme
-
 Mesocricetus auratus
3.4.24.86 tumor necrosis factor alpha converting enzyme
-
 Mesocricetus auratus